The poorest billion people are distributed throughout the world, though most are concentrated in rural sub-Saharan Africa and South Asia. Cardiovascular disease (CVD) data can be sparse in low- and middle-income countries beyond urban centers. Despite this urban bias, CVD registries from the poorest countries have long revealed a predominance of nonatherosclerotic stroke, hypertensive heart dis...

MOTIVATION Existing sequence assembly editors struggle with the volumes of data now readily available from the latest generation of DNA sequencing instruments. RESULTS We describe the Gap5 software along with the data structures and algorithms used that allow it to be scalable. We demonstrate this with an assembly of 1.1 billion sequence fragments and compare the performance with several othe...

Microarchitecture for Billion-Transistor VLSI Superscalar Processors Gabriel Hsiuwei Loh 2002 The vast computational resources in billion-transistor VLSI microchips can continue to be used to build aggressively clocked uniprocessors for extracting large amounts of instruction level parallelism. This dissertation addresses the problems of implementing wide issue, out-of-order execution, supersca...

Freshwater scarcity is increasingly perceived as a global systemic risk. Previous global water scarcity assessments, measuring water scarcity annually, have underestimated experienced water scarcity by failing to capture the seasonal fluctuations in water consumption and availability. We assess blue water scarcity globally at a high spatial resolution on a monthly basis. We find that two-thirds...

The ability to handle large scale graph data is crucial to an increasing number of applications. Much work has been dedicated to supporting basic graph operations such as subgraph matching, reachability, regular expression matching, etc. In many cases, graph indices are employed to speed up query processing. Typically, most indices require either super-linear indexing time or super-linear index...

An engulfment of a small bacterium by a larger archaeon more than a billion years ago resulted not in death, but in one of the most successful partnerships on earth. As you sit there, each of your cells (apart from your red blood cells) contains hundreds or thousands of the descendants of that bacterium, still earning their keep as part of that endosymbiotic deal struck in some ancient pool. Ho...

ING Group is a global financial services institution offering banking, insurance and asset management to 60 million private, corporate and institutional clients world-wide. ING has a market capitalisation of 23 billion euros and total assets of over 700 billion euros. Similar to other global financial institutions ING depends on information technology for delivering its services. Obviously, all...

A billion transistors on a single chip presents opportunities for new levels of computing capability. Depending on your design point, several distinct implementations are possible. In our view, if the design point is performance , the implementation of choice is a very high-performance uniprocessor on each chip, with chips interconnected to form a shared memory mul-tiprocessor. The basic design...

1. Fried TR, Tinetti ME, Towle V, O’Leary JR, Iannone L. Effects of benefits and harms on older persons’ willingness to take medication for primary cardiovascular prevention. Arch Intern Med. 2011;171(10):923-928. 2. Leipzig RM, Whitlock EP, Wolff TA, et al; US Preventive Services Task Force Geriatric Workgroup. Reconsidering the approach to prevention recommendations for older adults. Ann Inte...

A prime number p is called elite if only finitely many Fermat numbers 2 n + 1 are quadratic residues of p. Previously only the interval up to 10 was systematically searched for elite primes and 16 such primes were found. We extended this research up to 2.5 · 10 and found five further elites, among which 1 151 139 841 is the smallest and 171 727 482 881 the largest.