The concept of modulating or terminating seizure activity by brain stimulation is attracting considerable attention. The ability of such external excitatory stimuli to terminate repetitive bursting may depend upon identifiable parameters. We investigate the ability of external stimuli to terminate bursting under various conditions in defined neural network models. Networks of multiple neurons (...

To investigate the spatiotemporal properties of epileptiform activity in vitro, 400 microm-thick transverse hippocampal slices were prepared from juvenile rat and planar multi-electrode array (MEA) containing 60 electrodes was used to record the electrical activity induced by bath application of high potassium artificial cerebrospinal fluid (ACSF) on slices. Following successful induction of ep...

Both reward- and punishment-related stimuli are motivationally salient and attract the attention of animals. However, it remains unclear how motivational salience is processed in the brain. Here, we show that both reward- and punishment-predicting stimuli elicited robust bursting of many noncholinergic basal forebrain (BF) neurons in behaving rats. The same BF neurons also responded with simila...

Bursting neurons fire rapid sequences of action potential spikes followed by a quiescent period. The basic dynamical mechanism of bursting is the slow currents that modulate a fast spiking activity caused by rapid ionic currents. Minimal models of bursting neurons must include both effects. We considered one of these models and its relation with a generalized Kuramoto model, thanks to the defin...

Enterprises with existing IT infrastructure are beginning to employ a hybrid cloud model where the enterprise uses its own private resources for the majority of its computing, but then “bursts” into the cloud when local resources are insufficient. However, current approaches to cloud bursting cannot be effectively automated because they heavily rely on system administrator knowledge to make dec...

Neuron activity presents two timescales, a fast one related to action potential spiking, and a slow timescale in which bursting takes place. Some pathological conditions are related with the synchronization of the bursting activity in a weak sense, meaning the adjustment of the bursting phase due to coupling. We investigated coupled Rulkov maps network with randomly distributed parameters, and ...

Burst "ring is a prominent feature of cortical pyramidal cells and is thought to have signi"cant functional roles in reliable signaling and synaptic plasticity. Modeling studies have successfully elucidated possible biophysical mechanisms underlying complex bursting in pyramidal cells. Based on these results (Pinsky, Rinzel, J. Comput. Neurosci. 1 (1994) 39}60), we have built a simpli"ed two-co...

Synchronized cortical activities in the central nervous systems of mammals are crucial for sensory perception, coordination and locomotory function. The neuronal mechanisms that generate synchronous synaptic inputs in the neocortex are far from being fully understood. In this paper, we study the emergence of synchronization in networks of bursting neurons as a highly non-trivial, combined effec...

Pituitary cells of the anterior pituitary gland secrete hormones in response to patterns of electrical activity. Several types of pituitary cells produce short bursts of electrical activity which are more effective than single spikes in evoking hormone release. These bursts, called pseudo-plateau bursts, are unlike bursts studied mathematically in neurons (plateau bursting) and the standard fas...

In rat olfactory bulb slices, external tufted (ET) cells spontaneously generate spike bursts. Although ET cell bursting is intrinsically generated, its strength and precise timing may be regulated by synaptic input. We tested this hypothesis by analyzing whether the burst properties are modulated by activation of ionotropic gamma-aminobutyric acid (GABA) and glutamate receptors. Blocking GABA(A...