A 192-member library of N,N'-disubstituted urea inhibitors was synthesized by a solid-phase method. The ureas were tested for their inhibitory activities against recombinant human soluble epoxide hydrolase. Simple carbocyclic or para/meta-substituted phenyl groups showed inhibition potencies that were equal to or greater than adamantane-based sEH inhibitors, while the presence of bulky or ioniz...

A new [2.2]paracyclophane-based electron-rich and sterically bulky monophosphine ligand has been synthesized by an efficient and straightforward method. When combined with palladium, this ligand shows excellent performance in the Buchwald-Hartwig amination and Suzuki-Miyaura coupling reactions of various aryl chlorides. In both types of reactions, ortho-substituted, deactivated aryl chlorides a...

ω-Transaminase (ω-TA) is a promising enzyme for use in the production of unnatural amino acids from keto acids using cheap amino donors such as isopropylamine. The small substrate-binding pocket of most ω-TAs permits entry of substituents no larger than an ethyl group, which presents a significant challenge to the preparation of structurally diverse unnatural amino acids. Here we report on the ...

The donor properties of a set bulky ferrocene based bisphosphanes (Fe(C5H4PMes2)2 and (C5H4PMes2)Fe(C5H4PtBu2 with Mes= mesityl tBu=tert-butyl) were probed by exploring the NMR parameters corresponding selenophosphoranes amended cyclovoltammetry. ligand explored in complexation copper phenylacetylide which is relevant as intermediate Cu(I) catalyzed CO2 addition to phenylacetylene. Owing poor s...

Entry into a new class of tetra- and dicopper clusters was assisted by a fine steric tuning of bulky amidinate ligands that provide spin-delocalizing superexchange pathways in class III mixed-valence clusters, the properties of which are best understood without invoking metal-metal bonding.

Redetermination of the structure of the title compound, [Ge(SnMe(3))(4)] or [GeSn(4)(CH(3))(12)], previously refined from powder diffraction data only [Dinnebier, Bernatowicz, Helluy, Sebald, Wunschel, Fitch & van Smaalen et al. (2002 ▶). Acta Cryst. B58, 52-61], confirms that four bulky trimethyl-stannyl ligands surround the central Ge atom (site symmetry 1) in a tetra-hedral coordination.

A family of heteroleptic complexes of zinc and magnesium supported by bulky multidentate amino-ether phenolate ligands has been developed; in combination with external chain transfer agents, they constitute efficient binary catalytic systems for the immortal ring-opening polymerisation of cyclic esters.

A new series of N,N'-bis(2'-hydroxy-5'-substituted-benzyl)-N,N -dimethylethane-1,2-diamines (N,N'-dimethyltetrahydrosalen) ligands were prepared in good yield by reduction of the respective 3,3'-ethylene-bis(3,4-dihydro-6-substituted-2H-1,3-benzoxazine) precursors with sodium borohydride . The ligands were characterized by IR, NMR, and elemental analysis, which showed the compounds to be consis...