Normal subjects with bipolarity phenotype, even though not diagnosed bipolar disorder, are known to show distinct properties. In this study, we investigate the changes in molecular circadian rhythm after bright light exposure before sleep in normal subjects with bipolarity phenotype. 25 young male subjects were divided to 14 for bipolarity group and 11 for nonbipolarity group after scoring of t...

Normal subjects with bipolarity phenotype, even though not diagnosed bipolar disorder, are known to show distinct properties. In this study, we investigate the changes in molecular circadian rhythm after bright light exposure before sleep in normal subjects with bipolarity phenotype. 25 young male subjects were divided to 14 for bipolarity group and 11 for nonbipolarity group after scoring of t...

Normal subjects with bipolarity phenotype, even though not diagnosed bipolar disorder, are known to show distinct properties. In this study, we investigate the changes in molecular circadian rhythm after bright light exposure before sleep in normal subjects with bipolarity phenotype. 25 young male subjects were divided to 14 for bipolarity group and 11 for nonbipolarity group after scoring of t...

OBJECTIVE This trial assessed two novel nonpharmaceutical treatments for winter depression-naturalistic dawn simulation and high-density negative air ionization-delivered during the final hours of sleep. METHOD The patients were 99 adults (77 women and 22 men) with the winter seasonal pattern of major depressive disorder (94 cases) and bipolar II disorder (five cases). Five parallel groups re...

OBJECTIVES Studies have shown a shortening of the menstrual cycle following light exposure in women with abnormally long menstrual cycles or with winter depression, suggesting that artificial light can influence reproductive hormones and ovulation. The study was designed to investigate this possibility. DESIGN Placebo-controlled, crossover, counterbalanced order. SETTING Medical centres and...

Desipramine HCl, 10 mg/kg i.p. twice daily, produced subsensitivity to the hypothermic effects of nicotine, 1 mg/kg, after 1 and 2 weeks of treatment in male Sprague-Dawley rats, Phenelzine sulfate, fluoxetine HCl, and bright artificial light produced the same effect. The capacity of three chemically distinct classes of anti-depressants and bright artificial light (a treatment for seasonal depr...

Cumulative light-mediated damage to the retina over a long time period may be involved in the development of age-related retinopathies. Light is thought to produce retinal damage by initiating autoxidative reactions among the molecular components of the retina. Experiments were therefore conducted (1) to confirm that long-term differences in cyclic light intensity affect the rate of age-related...

This study examined the link between circadian rhythm changes due to bright light exposure and subthreshold bipolarity. Molecular circadian rhythms, polysomnography, and actigraphy data were studied in 25 young, healthy male subjects, divided into high and low mood disorder questionnaire (MDQ) score groups. During the first 2 days of the study, the subjects were exposed to daily-living light (1...

Previous studies suggest that light therapy, as used to treat seasonal affective disorder, may be beneficial for pre-menstrual depressive disorders. We conducted a six-menstrual cycle randomized, double-blind, counter-balanced, crossover study of dim vs. bright light therapy in women with late luteal phase dysphoric disorder (LLPDD). Fourteen women who met DSM-III-R criteria for LLPDD completed...