F18 2-Fluoro 2-deoxyglucose (FDG) has been the gold standard in positron emission tomography (PET) oncologic imaging since its introduction into the clinics several years ago. Seeking to complement FDG in the diagnosis of breast cancer using radio labeled fructose based analogs, we investigated the expression of the chief fructose transporter-GLUT 5 in breast cancer cells and human tissues. Our...

Tyrosine specific protein kinase activity was determined in 70 speci mens of the human mammary gland. These included 28 cancers of the breast, 21 benign breast diseases, and 21 normal breast tissues. We measured tyrosine kinase activity in the cytosol fraction and in the membrane fraction of the homogenates. In addition cytosolic aldolase activity was measured. Tyrosine kinase activity was dete...

Background & Objectives: Breast cancer is an aggressive cancer in females, worldwide and is the major cancer among Indian women. The cause of breast cancer includes environmental, genetic and hormonal factors. The present study is to analyse the expression of FOXO3a in Infiltrating Ductal carcinomas of breast cancer patients and corresponding normal tissues. Materials & methods: Formalin fixed ...

In this paper, the Monte Carlo simulation was used to simulate the diffuse reflectance of four breast tissues, which includes the normal breast tissue and three diseased human breast tissues (the breast fibroadenoma, the mastopathy and the breast cancer). The simulation was made in the wavelength of 633nm. To verify the simulations, experiments were done to measure the diffuse reflectance. The ...

Sporadic breast cancer develops through the accumulation of molecular abnormalities in normal breast tissue, resulting from exposure to estrogens and other carcinogens beginning at adolescence and continuing throughout life. These molecular changes may take a variety of forms, including numerical and structural chromosomal abnormalities, epigenetic changes, and gene expression alterations. To c...

Objective: Inhibition of lipid metabolism in breast cancer has been suggested as an effective approach for cancer therapy. Saffron-derived crocetin (Crt) and crocin (Cro) with the known anticancer activity, have shown hypolipidemic effect in diabetes and atherosclerosis. Here, we investigated the effect of Crt/Cro on lipid content in breast cancer. Materials and M...

Discriminant analysis of 16 trace element levels measured by ultramicro energy dispersive X-ray fluorescence in malignant and histologically normal human breast, colon, and lung tissues is shown to be a potentially valuable methodology for making malignant-normal and tis sue-type classifications. Linear composites of trace elements producing optimal malignantnormal discriminations are found to ...

Discriminant analysis of 16 trace element levels measured by ultramicro energy dispersive X-ray fluorescence in malignant and histologically normal human breast, colon, and lung tissues is shown to be a potentially valuable methodology for making malignant-normal and tissue-type classifications. Linear composites of trace elements producing optimal malignant-normal discriminations are found to ...

BACKGROUND Adenosine receptors (A1, A2A, A2B, A3) play an important role in the regulation of growth, proliferation and death of cancer and normal cells. We recently showed the expression profile of A2A and A2B receptors in normal and tumor breast tissues. In the present study, we used semiquantitative RT-PCR to measure the A1 and A3 gene expression levels in normal and tumor breast tissues. ...

Although molecular signatures based on transcript expression in breast cancer samples have provided new insights into breast cancer classification and prognosis, there are acknowledged limitations in current signatures. To provide rational, pathway-based signatures of disrupted physiology in cancer tissues that may be relevant to prognosis, this study has directly quantitated changed gene expre...