Radiation therapy delivered with hypofractionation, which involves the delivery of a higher dose per fraction in fewer fractions (generally with a lower total nominal dose) over a shorter overall treatment time, is an established therapeutic option at least for a selected group of early breast cancer patients after breast-conserving surgery. Optimal delivery of the tumor bed boost dose in terms...

Mammography is an x-ray examination of the breast usually done for breast cancer screening and accompanied by further development of both invasive and non-invasive radiological technique used for establishing the diagnosis of palpable and non palpable lesions [1,2]. The major projection for x-ray mammography includes cranio-caudal and mediolateral obliques view. There are two types of patients ...

Not all clinics have breath-hold radiotherapy available for left-breast irradiation. However intensity-modulated radiotherapy (IMRT) has also been advocated as a means of lowering heart doses. There is currently no large-scale, long-term follow-up data after breast IMRT and, since dose distributions may differ from classic tangent-based radiotherapy, caution is needed to avoid unexpected worsen...

BACKGROUND This study compared three methods of estimating the daily dose of fluoxetine to nursing infants and the relationship between these estimates and infant serum concentrations. METHODS Breast milk and infant serum concentrations of fluoxetine and norfluoxetine were obtained from 10 nursing mother-infant pairs. Quantification of daily infant dose was determined by three methods: 1) col...

Intensity modulated tangential photon beams for breast cancer treatment can improve the dose uniformity significantly throughout the whole breast and reduce the dose to the lung and the heart comparing with the conventional technique. Before the first treatment, patient setup may require a change on the collimator angle and/or the couch angle based on the chest wall coverage according to the po...

PURPOSE The purpose of this study was to explore the correlation between the respiration-induced target motion and volume variation with the dosimetric variance on breast and organ at risk (OAR) during free breathing. METHODS AND MATERIALS After breast-conserving surgery, seventeen patients underwent respiration-synchronized 4DCT simulation scans during free breathing. Treatment planning was ...

Introduction: Lymphatic mapping and sentinel node biopsy (LM/ SNB) techniques for melanoma and breast cancer management potentially expose staff, including operating theatre personnel, radiologists, pathologists and others, to ionising radiation. Aims: To ascertain exposure levels in a practical setting and to establish safe work practices for staff involved in the LM/ SNB procedure pathway. Me...

PURPOSE Noninvasive image-guided breast brachytherapy delivers conformal HDR (192)Ir brachytherapy treatments with the breast compressed, and treated in the cranial-caudal and medial-lateral directions. This technique subjects breast tissue to extreme deformations not observed for other disease sites. Given that, commercially-available software for deformable image registration cannot accuratel...

Aim: To evaluate the dosimetric outcomes of two different three dimensional conformal radiation therapy (3D-CRT) of concomitant boost delivery to the intact breast. Methods: Ten patients were evaluated using two standard opposed tangents conformal to the whole breast PTV, plus a pair of wedged fields conformal to the boost PTV; all fields have the same isocenter, placed in the whole breast plan...