BACKGROUND Postoperative cognitive dysfunction (POCD) is a significant clinical syndrome. Neuroinflammation is an important pathological process for POCD. However, it is not clear how systemic inflammation induced by surgery on peripheral tissues or organs is transmitted into the brain. We determined whether matrix metallopeptidase 9 (MMP9), a protein that can increase blood-brain barrier perme...

A 45-yr-old female patient was admitted with one-month history of headache and progressive left hemiparesis. Brain magnetic resonance imaging (MRI) demonstrated a mass lesion in her right frontal lobe. Her brain tumor was confirmed as a small cell glioblastoma. Her follow-up brain MRI, taken at 8 months after her initial surgery demonstrated tumor recurrence in the right frontal lobe. Contrast-...

Abstract OBJECTIVE The role of surgery in recurrent GBM remains a controversial topic. goal this study was to perform case-control analysis including time tumor recurrence as an additional prognostic factor order determine which patients benefit most from repeat surgery. METHODS Our brain database reviewed over ten-year period for all adult (≥ 18 years old) with primary IDH wildtype that receiv...

background: high-grade astrocytoma (grade 4) or glioblastoma multiforme (gbm) are deadly brain tumors. new therapies attempt to increase lifetime and quality of life in patients with malignant astrocytoma. o6-methylguanine-dna methyltransferase (mgmt) enzyme expression may be effective in prognosis and response to treatment of these patients. the aim of this study was assessment of mgmt enzyme ...

Post-operative respiratory depression is common in patients recovering from anesthesia and can result fatal cardiopulmonary collapse, anoxic brain injury, mortality. We report a case of 54-year-old morbidly obese female patient who developed transient hypoxemia after general anesthesia. The with obstructive sleep apnea (OSA) underwent breast excision surgery. At the end surgery, her muscle func...

Intraventricular tuberculoma (IVT) is extremely rare, CT and MRI patterns have been only sparsely described.  Herein, a case of intraventricular tuberculoma in a 40 year-old woman is reported.  At admission, the patient displayed malaise and was confused and deteriorated suddenly.  Brain CT and MRI findings were very similar to intraventricular meningioma.  The patient underwent surgery and tub...

we present a rare case with history of neurological symptoms due to multiple brain metastases and no urological symptoms. during patient evaluation for primary tumor, transitional cell carcinoma (tcc) of left renal pelvis was found. the patient underwent gamma knife stereotactic radio-surgery for the metastatic brain lesions. radical nephroureterectomy was performed, and a 4-cycle course of pac...

Background: Early diagnosis of brain tumors has significant effect on the treatment process. Brain metastatic tumors are usually diagnosed following the neurological symptoms in patients or incidentally after Computerized Tomography (CT) scan and Magnetic Resonance Imaging (MRI) requests of the brain. Objectives: Implementation of a new method for being informed about the origin of brain tumors...

Background: The effect of subthalamic nucleus deep brain stimulation (STN-DBS) on the voice features in Parkinson’s disease (PD) is controversial. No study has evaluated the voice features of PD underwent STN-DBS by the acoustic, perceptual, and patient-based assessments comprehensively. Furthermore, there is no study to investigate prosodic features before and after DBS in PD. The curren...