Despite the suggestions of several writers on the importance of convulsive seizures in infancy as an aetiological factor in the development of cerebral palsies, little attention is given to this association in the standard texts in general medicine and pathology, or even in the more special treatises on diseases of the nervous system. It is not altogether surprising, therefore, that convulsions...

The main goal of ischemic stroke treatment is rapid recanalization of the occluded blood vessel to limit brain injury and to salvage threatened cerebral tissue. To achieve early vessel recanalization, thrombolysis using recombinant tissue-type plasminogen activator is currently the only approved pharmacological intervention. Only recently, endovascular therapy has made its way into the clinic e...

abstract alzheimer’s disease (ad) is the most common cause of dementia in elderly people. the prevalence of alzheimer diseases is increasing in the world due to population aging. metabolic disease such as diabetes and obesity play important role in alzheimer disease. hyperglycemia can play important role in brain damage. it causes cognitive impairments, functional and structural alterations in ...

Preterm newborns represent a high-risk population for brain damage, primarily affecting the white matter, and for related neurodevelopmental disabilities. Determinants of brain damage have been extensively investigated, but there are still many controversies on how these factors can influence the developing brain and provoke damage. The concept of etiological pathway, instead of a single determ...

spinal cord injury (sci) is a trauma that disturbs motor, sensitive and autonomic function and directly impacts the quality of life. after physical damage, releasing of pro-inflammatory proteins and cytokines occurs and with collaboration of immune system cells, an immune response begins in the brain tissue. the result of neuroinflammation is edema, apoptosis and release of axonal growth inhibi...

one of the main problems following road accidents is brain injury after which death and disability in the most active population occurs. considering the fact that there is no definite clinical treatment for repair of damaged brain tissue, the present study examined the effects of autologous adult neural stem/progenitor cells (ns/pcs) seeded in a nanoscaffold named puramatrix in acute brain inju...

background: probiotics are microorganisms that may influence brain function via altering brain neurochemistry. new research evidence suggests that probiotic bacteria might protect tissue damage through diminishing the production of free radicals and/or inflammatory cytokines. therefore, this study was designed to evaluate the effects of probiotic bacteria on the prevention or reduction of brain...

primary and secondary malignant central nervous system (cns) tumors are devastating invasive tumors able to give rise to many kinds of differentiated tumor cells. glioblastoma multiform (gbm), is the most malignant brain tumor, in which its growth and persistence depend on cancer stem cells with enhanced dna damage repair program that also induces recurrence and resists current chemo- and radio...

A three-part mechanism is proposed for the induction of Alzheimer’s disease: (1) decreased blood lactic acid; (2) increased ceramide and adipokines; (3) folic acid. The age-related nature these mechanisms comes from age-associated muscle mass, visceral fat changes in diet. This also explains why many people do not develop disease. Simple lifestyle diet can prevent disease caused by a cascade ev...