Tryptoline and pinoline are two â-carbolines isolated from the nervous system of mammals. We have investigated the level of lipid peroxidation (LPO) in rat brain homogenates in the presence of nitric oxide (NO) which was released by the addition of sodium nitroprusside ( SNP ).We also examined the effect of other known antioxidants (vitamin E) on the NO-induced LPO. The concentration of malonal...

Three-day nitroglycerin (NTG) administration at progressively increasing doses caused a drop in the liver S-nitrosothiol (SNT) and malonyldialdehyde (MDA) concentrations below the control levels. It suggests that NTG administered in this way, exhibits antioxidant activity due to releasing the biologically active SNT and nitric oxide (NO). On the other hand, in the brain, NTG did not influence S...

Background: Nepeta dschuparensis Bornm (NP) is used as a medicinal herb in Iran. In traditional medicine, this herb is extensively employed for curing ailments such as cardiovascular diseases. NP has antioxidant and anti-inflammatory properties. This project examined the effects of the NP extract on cyclooxygenase-2 (COX-2) and interleukin-1β (IL-1β) protein levels and its efficacy in neuroprot...

Background: The oxidant-antioxidants balance in the living organism is constantly challenged by internal and external pressures. Maidenhair or Adiantum capillus-veneris (Acv) is rich in bioactive compounds with antioxidant effects.  Objectives: The present study aimed at investigating the effect of Acv hydroalcoholic extract on the oxidative stress rate of blood and brain of mice in the depres...

Oxidative stress may contribute to many pathophysiologic changes that occur after traumatic brain injury. In the current study, contemporary methods of detecting oxidative stress were used in a rodent model of traumatic brain injury. The level of the stable product derived from peroxidation of arachidonyl residues in phospholipids, 8-epi-prostaglandin F(2alpha), was increased at 6 and 24 h afte...

Recently, clinical trials of several neurodegenerative diseases have increasingly targeted the evaluation of the effectiveness of various antioxidants. The results so far are encouraging but variable and thus confusing. Rationale for the possible clinical effectiveness of antioxidants in several degenerative conditions has arisen out of the many years of basic science generally showing that rea...

The expression of most life history traits, such as immunity, growth and the development of sexual signals, is negatively affected by high levels of oxidative stress. Dietary antioxidants can reduce oxidative stress and have therefore been the focus of numerous studies in behavioural and evolutionary ecology in the last few decades. Most of this research has focused on carotenoids, neglecting a...

BACKGROUND Animals living in areas contaminated by radioactive material from Chernobyl suffer from increased oxidative stress and low levels of antioxidants. Therefore, normal development of the nervous system is jeopardized as reflected by high frequencies of developmental errors, reduced brain size and impaired cognitive abilities in humans. Alternatively, associations between psychological e...

ABSTRACT Goldfish are one of a few species able to avoid cellular damage during month-long periods in severely hypoxic environments. By suppressing action potentials excitatory glutamatergic neurons, the goldfish brain decreases its overall energy expenditure. Coincident with reductions O2 availability is natural decrease reactive oxygen (ROS) generation, which has been proposed function as par...

Background: Brain is an organ that prone to oxidative stress and subsequent apoptosis due high aerobic metabolism relatively low antioxidants, especially under hyperglycemic condition. Cinnamomum burmanii (CB) a species abundant in Indonesia, therefore it of special concern for researchers identify the anti-apoptotic effect CB. Objective: This study was initiated determine CB extract on inhibit...