Neuropsychological testing of patients in the course of their recovery from brain injuries enables analysis of cognitive deficiencies and/or emotional changes. The principle study objective was to define organic and/or reactive personality changes and the course of these changes in the function of the time span following brain artery aneurysm surgery in both female and male patients. The study ...

AIM To evaluate the feasibility of implanting 3D-printed brain aneurysm model in human cadavers and to assess their utility in neurosurgical research, complex case management/planning, and operative training. METHODS Two 3D-printed aneurysm models, basilar apex and middle cerebral artery, were generated and implanted in four cadaveric specimens. The aneurysms were implanted at the same anatom...

Since the papers of Beadles (1907), Fearnsides (1916), and Symonds (1924), there have been numerous publications on the clinical manifestations, prognosis, and treatment of spontaneous subarachnoid haemorrhage. The pathology of the brain has received less attention. Many accounts have been taken from routine necropsy reports and few have included detailed examinations of the brain. Intracerebra...

Cardiovascular pathologies, such as a brain aneurysm, are affected by the global blood circulation as well as by the local microrheology. Hence, developing computational models for such cases requires the coupling of disparate spatial and temporal scales often governed by diverse mathematical descriptions, e.g., by partial differential equations (continuum) and ordinary differential equations f...

To cite: Bonfield CM, Grandhi R, Jankowitz BT, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2014206130 DESCRIPTION A patient sustained a gunshot, which entered the nose and exited the parietal region. The patient was intubated, with reactive pupils and minimal extremity movement (Glasgow Coma Scale 3 T). Initial CTangiogram was unrevealing, but MRI perfo...

The objective of this review is to review the anaesthetic implications of vasoactive compounds particularly with regard to the cerebral circulation and their clinical importance for the practicing anaesthetist. Material was selected on the basis of validity and application to clinical practice and animal studies were selected only if human studies were lacking. Hypotensive drugs have been used ...

BACKGROUND AND PURPOSE Hemodynamics are thought to play an important role in the mechanisms of aneurysm pathogenesis, progression, and rupture. The purpose of this study was to define quantitative measures related to qualitative flow characteristics previously analyzed and to investigate their relationship to aneurysm rupture. MATERIALS AND METHODS The hemodynamic environments in 210 cerebral...

Bicuspid aortic valve is traditionally considered an innocuous congenital anomaly. Due to a better and widespread availability of non-invasive imaging techniques, it has come to the fore that 30% of these cases develop complications, viz., valve abnormality (aortic regurgitation and stenosis), and aneurysm of aortic root and ascending aorta. Sinus of Valsalva aneurysm is an uncommon complicatio...

 Cerebrovascular disease is one of the leading causes of death in the world, and about one-fourth of cerebrovascular deaths are due to ruptured cerebral aneurysms (CA). Hence it is important to find a way to reduce aneurysm formation and its subsequent morbidity and mortality. Proteolytic activity capable of lysing gelatin has been shown to be increased in aneurysm tissue and expressio...