STUDY DESIGN Review article, review of literature. OBJECTIVE To review the bone graft options that exist for posterolateral and posterior interbody lumbar fusion. SUMMARY OF BACKGROUND DATA As the number of lumbar fusion surgeries has increased over the last decade, alternative methods of grafting have been developed. Iliac crest autograft bone has traditionally been used for lumbar fusion....

STUDY DESIGN Fusion success with rhBMP-2 and autograft in titanium or PEEK corpectomy devices was evaluated in a sheep lumbar corpectomy model. The 6 treatment groups included titanium mesh or PEEK corpectomy devices filled with rhBMP-2 on a compression-resistant matrix (CRM) carrier; rhBMP-2 in a morselized absorbable collagen sponge (ACS) carrier combined with resorbable ceramic granules; and...

STUDY DESIGN The study was based on porcine posterolateral fusion model. OBJECTIVE The study aims to prove that polyelectrolyte complex (PEC) carrier could enhance the efficacy and safety profile of bone morphogenetic protein-2 (BMP-2). SUMMARY OF BACKGROUND DATA BMP-2 was introduced to enhance posterolateral fusion; however, extremely high doses of this molecule were often used which contr...

The purpose of this study was to quantify the levels growth factors (PDGF‐ AB, VEGF, IGF‐1, TGF‐β1) within bone samples at the fusion site of diabetic patients undergoing hindfoot fusion to determine any correlation with successful fusion. Methods The study included 10 adult diabetic subjects from one U.S. center, with an average age of 57.9 years (range 49‐71). Interventions included hindfoot ...

isolated skeletal metastasis to the bony calvarium is extremely rare in patients with squamous cell carcinoma of the uterine cervix. we describe the clinical and imaging findings in a case of squamous cell carcinoma of the uterine cervix with metastases to the bony calvarium as the sole site of metastasis. the patient was a 65-year-old woman with squamous cell carcinoma of the uterine cervix, f...

In three to five percent of active cases of tuberculosis, skeletal lesions develop. Typically, these occur on the vertebrae and are destructive in nature. In this paper, we examined cases of skeletal tuberculosis from a skeletal collection (Galler Collection) with focus on the manifestation of bony changes due to tuberculosis in various body regions in association with antibiotic introduction. ...

A 50 year-old woman was known with Klippel-Feil syndrome (KFS), consisting of a clinical triad of a short neck, low posterior hairline and restricted neck motion. She was complaining of new onset neck pain radiating down to midscapular region. Physical examination revealed moderate weakness of both biceps and polex muscles. She had diminished sensation of pinprick and light touch between C3-6 d...

OBJECTIVE To evaluate the efficacy of anterior cervical decompression, fusion and titanium plate fixation in sub axial cervical spine injuries in respect of neurological outcome, postoperative stability and early rehabilitation. The Descriptive case series study was conducted at Department of Neurosurgery, Liaquat University Hospital, Jamshoro, Sindh Pakistan during year 2005 to 2007. METHODS...

OBJECTIVE To explore the safety and efficacy of transpseudarthrosis osteotomy with interbody fusion in the treatment of Ankylosing Spondylitis (AS) patients with kyphotic spinal pseudarthrosis by a single posterior approach. METHODS Twelve consecutive patients with spinal pseudarthrosis underwent transpseudarthrosis osteotomy and interbody fusion with a polyetheretherketone (PEEK) cage by a s...