BACKGROUND Bone-targeted agents are widely used for the treatment of osteoporosis, the prevention of cancer-therapy induced bone loss, and for reducing the risk of skeletal related events in patients with metastatic disease. Despite widespread use, relatively little is known about the in vivo effect of these agents on bone homeostasis, bone quality, and bone architecture in humans. Traditionall...

background: excess amounts of lead in serum may affect different organ systems and cause lead poisoning. this toxicity mostly happens in chronic and occupational settings. this report comprises the clinical presentation of an acute case of lead toxicity with a much uncommon source of poisoning: opium. case presentation: a 25 year old man was presented to us with abdominal pain, nausea and vomit...

One of the greatest challenges when attempting to identify victims of mass fatality incidents is the analysis of DNA from bone. The bone is more difficult to process and extract for DNA. Additionally, the initial cleaning and sampling of the bone sample is a labor-intensive and time-consuming step prior to isolating DNA. Thus, it is difficult to adapt the current method for automation. In addit...

Limb elements in birds have been characterized as exhibiting a reduction in trabecular bone, thinner cortices and decreased bending strength when pneumatized, yet it is unclear if these characteristics generalize to the axial skeleton. Thin section techniques, the traditional gold standard for bone structure studies, have most commonly been applied to the study of avian bone. This destructive t...

To measure the speed of sound (SOS), most quantitative ultrasound (QUS) devices use the transmission mode, whereby two transducers are placed on opposite sides of the sample. This mode is limited to a few specific skeletal sites because of the varying configuration of bone geometry and varying amounts of overlying soft tissue at most other sites. The aim of this study was to address the depende...

The determination of regional blood flow utilizing fluorescent microspheres (FMs) is an established method for numerous organs. Recent progress, in particular the automation of sample processing, has further improved this method. However, the FM method (reference sample technique), which allows repetitive measurement of regional organ blood flow, has so far not been used for the determination o...

Histological analyses of fossil bones have provided clues on the growth patterns and life history traits of several extinct vertebrates that would be unavailable for classical morphological studies. We analyzed the bone histology of Hipparion to infer features of its life history traits and growth pattern. Microscope analysis of thin sections of a large sample of humeri, femora, tibiae and meta...

statement of the problem: cardiovascular disease and osteoporosis are major health dilemmas. osteoporotic patients frequently display vascular calcification that consequently increases the cardiovascular morbidity and mortality. purpose : this study aimed to investigate the relation of osteoporosis, vascular calcification (atheroma, intima-media thickness (imt)) and elongated styloid process (e...

chronic recurrent multifocal osteomyelitis (crmo) is an inflammatory bone disease usually affecting children. a 9-year old boy presented with recurrent lower extremities pain and discomfort lasting for two years. in every time, symptoms vanished after several weeks. the patient received antibiotics only in one period of bone pain. in other occasions the patient didn’t received any antibiotics. ...

objective: oral lesions are among the important reasons for seeking dental care. being frequently encountered, giant cell lesions form an important group of oral lesions. the epidemiologic data on these lesions, however, is scarce in iran. the present study investigated epidemiological and demographic characteristics of giant cell lesions in oral biopsies done in one of the largest oral patholo...