Extracellular matrix (ECM) remodeling is important during bone development and repair. Because matrix metalloproteinase 13 (MMP13, collagenase-3) plays a role in long bone development, we have examined its role during adult skeletal repair. In this study we find that MMP13 is expressed by hypertrophic chondrocytes and osteoblasts in the fracture callus. We demonstrate that MMP13 is required for...

Bone fracture is a complete or partial breakage of the bone structure. Fracture repair considered regenerative process whereby healing occurs through formation new tissue indiscernible from uninjured bone. reducing and realigning fractured ends together in other to achieve healing. Caffeine, 1, 3, 7-trimethylxanthine, an alkaloid present more than one hundred plant species. It used as stimulant...

A histologically normal insertion site does not regenerate following rotator cuff tendon-to-bone repair, which is likely due to abnormal or insufficient gene expression and/or cell differentiation at the repair site. Techniques to manipulate the biologic events following tendon repair may improve healing. We used a sheep infraspinatus repair model to evaluate the effect of osteoinductive growth...

Tendon and tendon-bone junction injuries, while heal, have high re-tear rates. Mesenchymal stem cells (MSCs) have great appeal for the promotion of tendon and tendon-bone junction healing because of their high proliferation rate, multi-potency and relative ease of isolation from various tissues. Tendon stem cells have been identified recently and could be an alternative new cell source for tend...

Transosseous repair of the rotator cuff has been shown to recreate the anatomic rotator cuff footprint in a secure and cost-efficient manner. However, the potential for sutures cutting through bone remains a concern with this strategy. Devices have been used successfully during open transosseous rotator cuff repair to augment the bone tunnels, potentially avoiding suture cut-out through the wea...

Okada K, Kawao N, Yano M, Tamura Y, Kurashimo S, Okumoto K, Kojima K, Kaji H. Stromal cell-derived factor-1 mediates changes of bone marrow stem cells during the bone repair process. Am J Physiol Endocrinol Metab 310: E15–E23, 2016. First published November 3, 2015; doi:10.1152/ajpendo.00253.2015.—Osteoblasts, osteoclasts, chondrocytes, and macrophages that participate in the bone repair proces...

Materials based on Mg2+-containing phosphates are gaining great relevance in the field of bone tissue repair via regenerative medicine methods. Magnesium ions, together with condensed phosphate play substantial roles process remodeling, affecting early stage regeneration through active participation osteosynthesis. In this paper we provide a comprehensive overview usage biomaterials magnesium a...

Rib segment, as one of the most widely used autologous boneresources for bone repair, is commonly isolated with an empty left in the defect. Although defective rib repair is thought to be unnecessary traditionally, it's of vital importance actually to promote rib regeneration for patients with better postoperative recovery and higher life quality. Comparative investigations on rabbit rib bone r...

Rotator cuff tears are common and cause a great deal of lost productivity, pain, and disability. Tears are typically repaired by suturing the tendon back to its bony attachment. Unfortunately, the structural (e.g., aligned collagen) and compositional (e.g., a gradient in mineral) elements that produce a robust attachment in the healthy tissue are not regenerated during healing, and the repair i...

albright syndrome is a rare condition, usually appears in the early years of life and characterized by bending or thickening of long bones. in girls, of endocrine glands disorders especially precocious puberty are the most common symptoms. also, brown pigments in the skin are another sing of this syndrome. certain mucosal and skin pigments are considerable features of the disease. etiology and ...