Giant cell tumors (GCT) of the bone are uncommon primary bone neoplasms that occur mainly in the epiphyses of long bones. However, GCT with tumoral growth in the cranium is rarely encountered, particularly in the temporal bone. GCT demonstrates benign histological features but is locally aggressive, and surgical excision is the treatment of choice. The authors describe a 31-year-old man who pre...

Phyllodes tumors are rare fibroepithelial neoplasms of the breast, classified as benign, borderline, or malignant based on histological features. Osseous metaplasia, characterized by presence bone formation within tumor, is an uncommon finding. This case report highlights rarity osseous metaplasia in a benign phyllodes tumor. A 23-year-old female presented with gradually enlarging lump left bre...

The diagnosis of polycythemia vera (PV) requires the integration of clinical and laboratory findings, bone marrow morphologic features, and JAK2 analysis. JAK2(V617F) (exon 14) mutation is found in 95% of PV cases. Functionally similar mutations in JAK2 exon 12 have also been described, but a thorough bone marrow study has not been done. We identified 7 PV cases with exon 12 mutations; all had ...

We report an easy, rapid method for quantifying bone isoenzyme of alkaline phosphatase (EC 3.1.3.1., ALP) in serum. The original method described by Rosalki and Ying Foo (Clin Chem 1984;30:1182-6) was somewhat simplified. In contrast to their results, we found that bone ALP is precipitated quantitatively by wheat-germ lectin. To check the clinical plausibility of the method, we used samples fro...

BACKGROUND Secondary myeloid neoplasms comprise a group of secondary diseases following exposure to myelotoxic agents or due to congenital diseases. The improvement of anticancer agents and immunosuppressive drugs seem to be associated with an increased incidence of secondary myeloid neoplasms. Karyotyping of bone marrow is essential for diagnosis and prognosis. Previous use of alkylating agent...

Mastocytosis is a heterogeneous group of rare diseases related to the clonal, neoplastic proliferation morphologically and immunophenotypically abnormal mast cells, that accumulate in one or more organ systems. Their pathophysiology dominated by activating mutations C-Kit (Stem Cell Factor receptor). Several pathological forms have been described ranging from isolated cutaneous mastocytosis aff...

It is essential to have a sound understanding of the nature and immunophenotypic characteristics of the normal cell populations encountered in bone marrow and peripheral blood. It is also important to have some understanding of lymphoid cellular interactions in the normal lymph node and thymus. This process is necessary if we are to understand the origin of the myeloid and lymphoid neoplasms en...

Background. The group of plasma cell neoplasms includes benign and malignant diseases. Sometimes there are difficulties in making a diagnosis. study the diagnostic prognostic significance immunohistochemical (IHC) markers is current interest. Aim. To IHC histological features bone marrow primary diagnosis patients with multiple myeloma (MM) monoclonal gammopathy undetermined (MGUS). Materials m...

INTRODUCTION Minor salivary gland neoplasms of epithelial origin are rare in children and adolescents and most are not well documented, except for a few small series and case reports. This study represents a retrospective clinical analysis of nine cases of benign epithelial salivary gland neoplasms accessioned over a 35-year period at the Louisiana State University School of Dentistry and combi...