We investigated the effects of dietary iron deficiency on bone metabolism by measuring markers of bone turnover in rats. Twelve 3-week-old male Wistar-strain rats were fed a control diet or an iron-deficient diet for 4 weeks. Dietary iron deficiency decreased hemoglobin concentration and increased heart weight. Serum osteocalcin concentration, bone mineral content, bone mineral density, and mec...

osteoporosis is a major health problem because of the large health care costs associated with its clinical consequences. it is therefore of great importance to identify modifiable risk factors. we investigated association between fruit and vegetables intake and bone mineral density in rural population of tehran surroundings. subjects were a subgroup of a large study on prevalence and causes of ...

Tendon attaches to bone across a functionally graded interface, "the enthesis". A gradient of mineral content is believed to play an important role for dissipation of stress concentrations at mature fibrocartilaginous interfaces. Surgical repair of injured tendon to bone often fails, suggesting that the enthesis does not regenerate in a healing setting. Understanding the development and the mic...

Bone is a composite biomaterial mainly composed of packed collagen fibres and nano-sized hydroxylapatite (HA) crystals. Quantitative measurements of bone mine­ ral composition can provide insights into the bone mine­ ral formation in health and disease . Bone mineral characteristics such as crystal lini ty, carbonate and phosphate mineral content may vary as a function of age, sex, diet, bone l...

Although concerns over the environmental impact of excess P in the excreta from pig production and governmental regulations have driven research toward reducing dietary supplementation of P to swine diets for over a decade, recent dramatic increases in feed costs have further motivated researchers to identify means to further reduce dietary P supplementation. We have demonstrated that genetic b...

Ca nutritional requirements and bone Ca turnover can be assessed using numerous techniques. Among these techniques are bone mass measurements, tracer kinetic studies, bone histomorphometry and biochemical studies. Stable-isotope-based kinetic studies offer unique advantages in their ability to assess both Ca absorption and turnover. This approach is safe and readily applicable to subjects of al...

Silicon and boron share many similarities, both chemically and biochemically, including having similar effects on bone, although their mechanisms of action are not known. Here we compared the loading of silicon and boron into bone, their localization and how they are influenced by age (growth & development), to obtain further clues as to the biological effects of these elements and, especially,...

BACKGROUND AND PURPOSE Osteoporosis is a common skeletal disorder with costly complications and a global health problem and one of the leading causes of morbidity and mortality worldwide. Magnetic field therapy and physical activity have been proven as beneficial interventions for prevention and treatment of osteoporosis. The purpose of this study was to compare the response of bone mineral con...

Bone is a dynamic tissue which is continuously adapting not only to external mechanical stimuli but also to internal metabolic calcium demands. During normal bone remodeling, bone-resorbing osteoclasts release calcium from the bone and digest the collagenous bone matrix, after which bone-depositing osteoblasts form unmineralized collagen matrix, which subsequently mineralizes. The detailed mech...

The mechanical properties of bones are greatly influenced by the ratio of organic constituents to mineral. Determination of bone mineral content on a macroscopic scale is straightforward, but microscopic variations, which can yield new insights into remodelling activities, mechanical strength, and integrity, are profoundly more difficult to measure. Measurement of microscopic mineral content va...