activity is through modification in bone turnover which occurs through two fundamentally different processes, i.e. modeling and remodeling with the activities of osteoblast and osteoclast cells in the mechanisms of bone formation and bone resorption [3]. A number of biochemical assays have been described for measuring serum and urinary concentration of markers of bone metabolism [4] that allow ...

This study was conducted to investigate the correlation between lipid-lowering and bone-protective effects of eicosapentaenoic acid on steroid-induced bonechanges in rats. Twenty-one male 10-week-old Wistar rats were divided into 3 groups (n = 7 each) and treated with 0.9% NaCl SC (group 1) or methylprednisolone 7 mg/kg SC once a week (group 2) or methylprednisolone 7 mg/kg SC once a week + eic...

The principal hormones involved in calcium metabolism and bone remodeling are parathyroid hormone (PTH), calcitonin, and vitamin D (D3). Other hormones, such as the thyroid hormones, growth hormone, androgens, estrogens, and the glucocorticoids also influence mineral homeostasis and bone metabolism. The three primary target tissues for these hormones are bone, kidney, and intestine. These three...