Circulating fibrocytes play a key role in the pathogenesis of pulmonary fibrosis. Fibrocytes are bone marrow-derived leukocytes, which enter the lungs in response to their chemoattractant CXCL12 and differentiate into fibroblasts or myofibroblasts, leading to excess deposition of the collagen-rich extracellular matrix. Matrix metalloproteinase (MMP)-9 and MMP-2, secreted by fibrocytes, degrade ...

Abstract Study question Can we use CD133+ bone marrow derived stem cell (BMDSCs) loaded scaffolds to aid endometrial regeneration locally in Asherman syndrome (AS)? Summary answer Gelatin supported transdifferentiation via decidualization of BMDSCs. Implantable showed a certain degree recovery an AS rat model. What is known already We have demonstrated that BMDSCs contribute proliferation, and ...

A technique for the formation of gelatin thin films and composite coatings with silicon dioxide zinc oxide nanoparticles by spin coating has been developed. New data morphology structural characteristics formed nanocomposite were obtained atomic force microscopy. The dependences roughness parameters on content in polymer matrix are presented. It shown that introduction inorganic into structure ...

-Several methods for assessing the preservation of the organic and inorganic components of bone are discussed. Aspects of bone composition (i.e. specific trace element concentrations and stable isotope ratios) provide information on diet and health status in prehistoric and fossil humans. Such information is valuable in understanding the evolution of human adaptation but, prior to the analysis ...

Gelatin is one of the most popular natural polymers which widely used in food, pharmaceutical, biomedical and cosmetic industries. The gelatin has been prepared from different sources such as porcine skin, cattle bone, fish, etc. Depending on type acidic alkali extraction processes A B were obtained. This chapter provides a comprehensive overview preparation base hydrogel. Furthermore, we evalu...

Our laboratory utilized biomimicry to develop a synthetic bone scaffold based on hydroxyapatite-gelatin-calcium silicate (HGCS). Here, we evaluated the potential of HGCS scaffold in bone formation in vivo using the rat calvarial critical-sized defect (CSD). Twelve Sprague-Dawley rats were randomized to four groups: control (defect only), decellularized bone matrix (DECBM), and HGCS with and wit...

BACKGROUND The major types of commercially available gelatin hydrolysates are prepared from mammals or fish. Dietary gelatin hydrolysates from mammals were reported to improve bone mineral density (BMD) in some animal models. In contrast, there is limited study showing the effects of dietary gelatin hydrolysates from fish on BMD. The quantity and structure of peptides in the plasma after oral a...