The bone marrow examination is invaluable in the diagnosis of certain haematological and non haematological conditions. The diagnosis of haematological disorders is achieved mainly by the examination of peripheral blood and bone marrow aspirate smears. Although bone marrow histology can provide additional information, for many technical reasons, trephines are not so popular and their diagnostic...

Benign metastasizing leiomyoma (BML) is a very rare condition and is characterized by the presence of benign smooth muscle tumours in organs distant from the uterus, most commonly the lung. It generally affects women of reproductive age and prognostic is usually excellent. However, the course of the disease is unpredictable. We report here the case of a 76-year-old woman with a previous medical...

it is estimated that annually 10 million people are affected by traumatic brain injury and it is one of the major causes of death and disability in accidents. studies have shown the potential therapeutic value of neural stem cell therapies. also, neural stem cell motility and migration to the site of injury has a great regeneration value of the damaged tissues. extracellular and intracellular f...

background: bone marrow-derived mesenchymal stem cells (bmmscs) transplantation has been considered as a promising milestone in liver fibrosis treatment. however, low amounts of homing are a major obstacle. we aimed to investigate the role of melatonin pretreatment in bmmsc homing into experimental liver fibrosis. methods: bmmscs were obtained, grown, propagated and preconditioned with 5 µm mel...

New-onset pancytopenia can be caused by a wide variety of etiologies, leading to a diagnostic dilemma. These etiologies range from congenital bone marrow failure to marrow space-occupying lesions, infection, and peripheral destruction, to name a few. Bone marrow examination, in addition to a detailed clinical history, is often required for an accurate diagnosis. The purpose of this review is to...

Bone is the most common site to which breast cancer metastasizes and sometimes first affected in a substantial proportion of women with advanced cancer. A lot study has highlighted that imaging modalities visualize different aspects osseous tissues (cortex or marrow). Imaging bone metastases problematic because lesions can be osteolytic, osteoblastic, mixed, are based on either direct anatomic ...

The bone is the third most common site of cancer metastasis. To invade the bone, tumor cells produce osteoclast-activating factors that increase bone resorption by osteoclasts. Here we report that human neuroblastoma cells that form osteolytic lesions in vivo do not produce osteoclast-activating factors but rather stimulate osteoclast activity in the presence of human bone marrow mesenchymal st...

A study of seven patients with AILD has confirmed previously reported cytological and immunological changes in the peripheral blood. In themselves these changes should not be considered as specific. Histological examination of the bone marrow may show more characteristic lesions which involve haemopoietic, lymphoid, and stromal cells. Three patients had bone marrow features similar to myelofibr...

We report a case of intrathoracic extramedullary hematopoiesis associated with hemolytic anemia. While the paravertebral localization of the lesions demonstrated on CT and MRI was suspicious of intrathoracic extramedullary hematopoiesis, In-111 chloride and Tc-99m Sn colloid bone marrow scintigraphies showing a bone marrow element of the lesion were useful to confirm the diagnosis.

Imatinib mesylate is an effective, small-molecule, selective tyrosine kinase inhibitor, which inhibits BCR-ABL in patients with chronic myeloid leukemia, c-kit gastrointestinal tumor (GIST), and platelet-derived growth factors hypereosinophilic syndrome. Above all, bone marrow necrosis a rare complication of imatinib usage. If newly developed increased opacity lesions are seen metastatic GIST, ...