UNLABELLED The effects of lovastatin therapy on the parameters of body cholesterol metabolism were explored in nine hypercholesterolemic patients. Long-term cholesterol turnover studies were performed before therapy, and were repeated after 15 mo of lovastatin therapy (40 mg/d) while continuing on therapy. The major question addressed was whether a reduction in plasma cholesterol level with lov...

—Appropriate and relevant measures of body size are essential to understand scaling relationships or to compare morphometric data from specimens or taxa of different sizes. Traditionally, body mass and snout–vent length have been used as measures of body size in lizards. Here, we report on the relevance of an alternative measure of size, skeletal mass, which is highly correlated with traditiona...

data is expected to be small, as the brain sizes of several adult specimens and their body masses are typically recorded, and thus the body mass range of individualbased body mass data is expected to approximate that of the averages of the literature. It is therefore not surprising that studies of body mass versus brain sizes have successfully used both literature-based [Isler and Van Schaik, 2...

CC-BY-NC 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not. 2 SUMMARY A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Pe...

The purpose of the experiment was threefold: (a) To find evidence that grasping is body-scaled and thus remains invariant during development; (b) to seek evidence that the body-scaled ratio of cube and hand size serves as a control parameter for the phase transition from one-handed to two-handed grasping by identifying the presence of sudden jump, enhanced variance, multistability, and hysteres...

A major constraint on the evolution of large body sizes in animals is an increased risk of developing cancer. There is no correlation, however, between body size and cancer risk. This lack of correlation is often referred to as 'Peto's Paradox'. Here, we show that the elephant genome encodes 20 copies of the tumor suppressor gene TP53 and that the increase in TP53 copy number occurred coinciden...