PURPOSE Lipofuscin (LF) accumulation in the retinal pigment epithelium (RPE) is associated with age and various retinal diseases. Toxic LF compounds may interfere with normal RPE function. Oxidative modification of proteins was determined in LF granules from human eyes. METHODS LF was isolated from the RPE-choroid complex of 10 pairs of donor eyes by gradient ultracentrifugation. Protein comp...

Red-meat lipid peroxidation in the stomach results in postprandial oxidative stress (POS) which is characterized by the generation of a variety of reactive cytotoxic aldehydes including malondialdehyde (MDA). MDA is absorbed in the blood system reacts with cell proteins to form adducts resulting in advanced lipid peroxidation end products (ALEs), producing dysfunctional proteins and cellular re...

Lipid peroxidation is a degenerative chain reaction in biological membranes that may be initiated by exposure to free radicals. This process is associated with changes in the membrane fluidity and loss of several cell membrane-dependent functions. 5-methoxytryptophol (ML) is an indole isolated from the mammalian pineal gland. The purpose of this study was to investigate the effects of ML (0. 01...

AIM To determine the existence and level of oxidative stress caused by lipid peroxidation in pregnancy. METHODS The research was conducted as prospective examination that included 60 healthy women (age 18-45). The women included in the examination were divided into two groups. The group I (N-31) included women in the first trimester of normal, healthy pregnancy. The group II included healthy ...

background: lipid peroxidation is a free radical-generating process which occurs on every membranous structure of the cell. free radicals are known to be involved in a number of human pathologies including atherosclerosis. the purpose of this cross-sectional study was to examine the association between pre-hypertension status and oxidative stress markers [total antioxidant capacity (tac) and ma...

BACKGROUND The aim of this study was to evaluate the plasma concentrations of malondialdehyde (MDA) and nitric oxide (NO) and the plasma activities of oxidant and antioxidant enzymes in patients with IBS. MATERIAL/METHODS A total of 36 patients with IBS were included in the study. Thirty-five healthy subjects were selected to form the control group. Superoxide dismutase (SOD), catalase (CAT),...

Objective(s): Evaluation of nanomaterials interaction with blood ingredients is a part of preclinical risk assessment of newly-synthesized materials, especially for nano-sized pharmaceuticals which are intravenously administrated. The red blood cells (RBCs) are susceptible to oxidative stress damage. This study was designed to evaluate induced oxidative hematotoxic effect of na...

Background: The present study aims to examine the pharmacotherapy effects of citicoline in patients suffering traumatic brain injury with DAI and GCS less than or equal to 8 diagnosis. The treatment efficacy of citicoline was assessed by the malondialdehyde (MDA) levels in plasma as a marker of oxidative stress and GCS clinical assessment of patients. Furthermore, because of the relation betwee...

Type 2 diabetes mellitus is a chronic progressive disease characterised by hyperglycaemia and dyslipidemia which leads to the development of vascular complications. Hyperglycaemia overloads glucose metabolic pathways and increases non-enzymatic, auto-oxidative glycosylation and free radical production. Dyslipidemia favours free radical-induced lipid peroxidation and increased deposition of oxid...