background: designing the effective and early interventions can prevent progression of prediabetes to diabetes. few studies have shown the effect of flaxseed on glycemic control. this study aimed to assess the effect of flaxseed powder on insulin resistance (ir) indices and blood pressure in prediabetic individuals. materials and methods: in a randomized clinical trial, 99 prediabetic individua...

Complicated and extensive models of glucose regulation, involving several variables, have been developed over the years. Our research specifically focuses on the feedback loop between insulin and glucagon. Although our model is simpler than a model including state variables such as non-esterified fatty acids concentration in the blood plasma, β-cell mass, TAG content of lipocytes, and/or leptin...

INTRODUCTION To obtain strict glucose regulation, an accurate and feasible bedside glucometry method is essential. We evaluated three different types of point-of-care glucometry in seriously ill intensive care unit (ICU) patients. The study was performed as a single-centre, prospective, observational study in a 12-bed medical ICU of a university hospital. METHODS Patients with an expected ICU...

Glucagon-like peptide-1 (GLP-1) acts to control blood glucose via multiple mechanisms, including regulation of insulin and glucagon secretion, gastric emptying, satiety, and peripheral insulin sensitivity. However, the relative importance of these actions for regulation of blood glucose remains unclear. We demonstrate here a gene dosage effect for the incretin action of GLP-1, as heterozygous G...

In this computational study we consider a generalized minimal model structure for the intravenously infused insulin-blood glucose dynamics, which can represent a wide variety of diabetic patients, and augment this model structure with a glucose rate disturbance signal that captures the aggregate effects of various internal and external factors on blood glucose. Then we develop a model-based, sw...