Background: Colorectal cancer (CRC) is the third most common cancer worldwide. Studies have indicated that immune cells and soluble factors play a key role in maintaining the balance between tumor-promoting inflammation and anti-tumor immunity. It has been shown that secreted cytokines from CRC cell lines could affect peripheral blood mononuclear cells (PBMCs), monocytes, and macrophages phenot...

objective: menstrual blood stromal stem cells (mbscs) share some phenotypic and functional similarities with mesenchymal stem cells (mscs). mscs are shown to inhibit either the function or generation of different immune cells, including dendritic cells (dcs). however, data regarding mbscs’ potential effects on immune system cells are elusive. here, we examine whether mbscs affect the generation...

introduction: hematopoietic stem cells are always in a quiescence state. since they need retroviral transduction to infect dividing cells, they are resistant to retrovirus transduction. they need to be pre-stimulated by a cytokine cocktail. for proliferation without maturation, we suggest mip-1α as a novel factor. material and methods: retroviral vector produced by pg13/ln c8 cells titter on he...

The cytotoxic activity of natural killer cells is usually tested by radioactive assay CSI Cr release assay), which detects the release of cytoplasmic contents after plasma membrane disintegration of dying cells. In contrast to this indirect evaluation of cytotoxicity, the assessment of cell damage by flow cytometry aims to provide a more exact characterization of the death pathway via detec...

This study was conducted to compare the effects of diets Borage Powder and control (no additives diets) on broiler’s average blood cell counts and immune system on the broiler chicks. Sixty four male broiler chicks (Ross 308) randomly allocated into one of two treatments with four replicates of eight chickens based on a completely randomized block design.  Diets were include control (no additiv...

objectives the aim of this study was to evaluate the biological effects of opium on the number of peripheral blood cells and red blood cells (rbcs) indices in diabetic rats. materials and methods peripheral blood samples were collected from diabetic, opium-addicted, diabetic opium-addicted and normal male and female rats and hematological parameters were measured. results the mean number of whi...

background : cytokines produced by different subsets of t cells are the key mediators to adjust the quality of immune responses. despite evidence of induction of an immune reaction against tumors such as breast cancer, not all responses are protective. in this study we attempt to evaluate the expression profile of several cytokines from the t helper 1 and 2 subsets in blood cells from patients ...

Background: understanding the genomic alteration induced by ionizing radiation still remains to be a methodological challenge in genetic field. The energy released from this type of radiation can potentially causes structural and numerical alterations in lymphocytes, which in turn converts them into abnormal tumor cells. Chromosomal abnormalities associated with specific type of hematological m...

In healthcare systems, one of the important actions is related to perishable products such as red blood cells (RBCs) units that its consumption management in different periods can contribute greatly to the optimality of the system. In this paper, main goal is to enhance the ability of medical community to organize the RBCs units’ consumption in way to deliver the unit order timely with a focus ...