BACKGROUND In Idiopathic Dilated Cardiomyopathy (IDC) an imbalance between myocardial oxygen consumption and supply has been postulated. The ensuing subclinical myocardial ischemia may contribute to progressive deterioration of LV function. beta-blocker is the therapy of choice in these patients. However, not all patients respond to the same extent. The aim of this study was to elucidate whethe...

In a study on 138 hypertensive non-insulin dependent diabetic subjects, factors influencing lipoproteins were assessed. Multiple regression analyses were carried out in order to assess the influence of f-blocker antihypertensive therapy while making allowances for other confounding variables. In males, but not in females, on a ,B-blocker for hypertension, total high density lipoprotein(HDL-) an...

Cardiovascular disease is one of the most important causes of death in the world. There are variety of plans and strategies to treatment and prevention of CVD. Medicines have significant role to reach the goals. Ensuring Affordability of medicines is very crucial to success in these programs. The impoverishment method which focuses on the impoverishing effect of the purchasing of medicines is o...

Despite the current advances in treatment, acute decompensated heart failure accounts for more than 1 million hospital admissions annually. Many of the patients hospitalized are already receiving long-term treatment with beta-blockers. For patients who receive full dose beta-blocker therapy and suffer acute decompensated heart failure, clinicians face two key questions: what to do, if anything,...

BACKGROUND The Ontario Blood Pressure (ON-BP) survey reported high treatment and control rates for hypertension in the province of Ontario, Canada, in a survey performed in 2006. This study examined patterns of utilization of antihypertensive drug classes and their impact on blood pressure (BP) control. METHODS Cross-sectional, population-based survey of adults, 20-79 years of age (population...

Rationale & ObjectiveDespite alpha blockers’ use for hypertension as add-on therapy in hemodialysis patients, scant information is available on their association, especially with safety, these patients.Study DesignProspective cohort study.Setting ParticipantsHemodialysis patients receiving antihypertensive agents the Japan Dialysis Outcomes and Practice Patterns Study, Phases 4 to 6 were analyz...

OBJECTIVES We evaluated the use and effectiveness of beta-blocker therapy after acute myocardial infarction (AMI) for elderly patients with chronic obstructive pulmonary disease (COPD) or asthma. BACKGROUND Because patients with COPD and asthma have largely been excluded from clinical trials of beta-blocker therapy for AMI, the extent to which these patients would benefit from beta-blocker th...

BACKGROUND In response to the short-term negative inotropic and chronotropic effects of β-blockers, heart failure (HF) guidelines recommend initiating β-blockers at low dose with gradual uptitration as tolerated to doses used in clinical trials. However, patterns and safety of β-blocker intensification in routine practice are poorly described. METHODS We described β-blocker intensification am...