Although Keilin and Hartree (1934) and Blaschko (1935) have shown that sodium azide inhibits catalase derived from animal tissue, there is no information about its action on bacterial catalase. It seemed therefore desirable to make a quantitative study of the effects of sodium azide on catalase derived from this source. Since peroxides are metabolic products of many organisms, the inhibition of...

DESCRIPTION A3-day-old female baby born by normal delivery following an uncomplicated pregnancy presented with blisters on her legs. These blisters were present since birth and were diagnosed as staphylococcal skin infection and treatedwith oral flucloxacillin and the baby was discharged home. She was referred to our hospital on day 3 as the rash was getting worse. The baby was feeding well and...

PURPOSE To describe a case of a child with a known history of pigmentary mosaicism suggestive of Hypomelanosis of Ito presenting with unilateral leukocoria, who was ultimately diagnosed with retinoblastoma. METHODS A report of a 16-month-old girl with pigmentary mosaicism and unilateral retinoblastoma. RESULTS A previously healthy 16-month-old girl with a diagnosis of a mosaic hypopigmentat...

Incontinentia pigmenti (IP), is an X linked dominant disorder featuring blistering and hyperpigmentation along the lines of Blaschko. Genetically, a single large intragenic deletion spanning exons 4–10 IKBKG gene has been identified as cause IP in ∼80% all cases. Females with usually survive due to chromosome inactivation. However, nearly males typically die utero. Survival can be explained by ...

The ocular and systemic changes in incontinentia pigmenti are reviewed here and a case is reported with fundus changes which have not been described previously. Incontinentia pigmenti (IP) is characterised by ectodermal defects, with occasional associated mesodermal abnormalities. The typical skin lesions are blue-grey to chocolate-brown arranged along the naevus lines of Blaschko. These occur ...

1. Tilly JJ, Drolet BA, Esterly NB. Lichenoid eruptions in children. J Am Acad Dermatol. 2004;51:606-24. 2. Aloi F, Solaroli C, Pippione M. Diffuse and bilateral lichen striatus. Pediatr Dermatol. 1997;14:36-8. 3. Mittal R, Khaitan BK, Ramam M, Verma KK, Manchanda M. Multiple lichen striatus-An unusual presentation. Indian J Dermatol Venereol Leprol. 2001;67:204. 4. Peramiquel L, Baselga E, Dal...

We report on a 22 year old man with hyperpigmentation distributed along the lines of Blaschko in whom cytogenetic analysis showed mosaicism for an unusual supernumerary marker chromosome. The patient was of normal intelligence and was not dysmorphic. The marker was present in 30% of his lymphocytes and in 6% of his skin fibroblasts from a dark area, while fibroblasts from a light area showed a ...

Pigmentary mosaicism of Ito (PMI) is a skin abnormality often characterized by hypopigmentation of skin, following, in most cases, the Blaschko lines, usually associated with extracutaneous abnormalities, especially abnormalities of the central nervous system (CNS). It is suggested that this pattern arises from the presence and migration of two cell lineages in the ectoderm layer during the emb...

Patterns form with the break of homogeneity and lead to the emergence of new structure or arrangement. There are different physiological and pathological mechanisms that lead to the formation of patterns. Here, we first introduce the basics of pattern formation and their possible biological basis. We then discuss different categories of skin patterns and their potential underlying molecular mec...

OBJECTIVE To analyze the distribution of manifestations in a pediatric cohort and define guidelines for follow-up of incontinentia pigmenti (IP). DESIGN Retrospective study of 47 children referred to the Department of Pediatric Dermatology with a diagnosis of IP between 1986 and 1999. SETTING The private or institutional practice of participating dermatologists and pediatricians. MAIN OUT...