The fixed oil of black cumin seeds, Nigella sativa L. (NSO), has shown considerable antioxidant and anti-inflammatory activities. Chronic cerebral hypoperfusion has been linked to neurodegenerative disorders including Alzheimer's disease (AD) and its subsequent cognitive impairment in which oxidative stress and neuroinflammation are the principal culprits. Cerebrovascular hypoperfusion was expe...

Six rare naturally occurring indazole-type alkaloids including two new compounds, 17-O-(β-d-glucopyranosyl)-4-O-methylnigellidine (1) and nigelanoid (2), and four known compounds (3-6) were isolated from a defatted extract of Nigella sativa (black cumin) seeds. 17-O-(β-d-Glucopyranosyl)-4-O-methylnigellidine (1) increased glucose consumption by liver hepatocytes (HepG2 cells) through activation...

BACKGROUND Bitter cumin (Centratherum anthelminticum (L.) Kuntze), is a medicinally important plant. Earlier, we have reported phenolic compounds, antioxidant, and anti-hyperglycemic, antimicrobial activity of bitter cumin. In this study we have further characterized the antioxidative activity of bitter cumin extracts in various in vitro models. METHODS Bitter cumin seeds were extracted with ...

The black cumin (Nigella sativa) "NS" or the black seeds have many pharmacological activities such as antioxidant, anticarcinogenic, antihypertensive, and antidiabetic properties. In this work, streptozotocin-induced diabetic rats fed with a high-fat diet were treated daily with NS oil (NSO) in order to study the effect on the blood glucose, lipid profile, oxidative stress parameters, and the g...

introduction cumin (cuminum cyminum l.) is an annual plant that commonly cultivated in arid and semiarid regions of iran. the crop has a wide range of uses including medicinal, cosmetic and food industry. cumin occupies about 26% of total area devoted to medicinal plants in iran. however, cumin is seriously affected by the fusarium wilt and blight diseases. the diseases usually increase under w...

Objective: The objective of the study was to determine effect consumption black cumin seed oil (BCSO) on platelet count, clotting time (CT), and bleeding (BT) in healthy-smoker volunteers (HSV).
 Methods: Participants were 39 healthy male smokers aged 18-66 y. divided into four groups randomly. treatment group received BCSO for thirties days 3x1, 3x2, 3x3 capsules/day doses. placebo a prep...

This study was performed to evaluate the phenolic profile, antioxidant and diuretic effects of black cumin and lady-in-a-mist seeds. In the phenolic profile, differences between the two species are significant. Qualitative and quantitative analyses of the phenolic compounds were performed using a HPLC-UV/MS method. Hyperoside was the only identified flavonoid glycoside (1.08 ± 0.01 μg∙g-1 dw pl...

Black cumin (Nigella sativa) is a spice having medicinal properties with pungent and bitter odour. It is used since thousands of years to treat various ailments, including cancer mainly in South Asia and Middle Eastern regions. Substantial evidence in multiple research studies emphasizes about the therapeutic importance of bioactive principles of N. sativa in cancer bioassays; however, the exac...

A total of 270 fingerlings of Asian sea bass (Lates calcarifer) were allotted into three equal treatments with three equal replicates for each to investigate the effect of dietary supplementation of two levels of Black cumin seeds (Nigella sativa) and Turmeric (Curcuma longa) mixture (BTM) on growth performance and blood chemistry throughout the experimental period (98 days). Fish of the first ...

The antibacterial activity of essential oils hydrodistilled from local anise, coriander, cumin, marjoram, rosemary and thyme were screened against a group of food-borne pathogens comprising Staphylococcus aureus, Listeria monocytogenes, Escherichia coli, Escherichia coli O157:H7, Salmonella Typhimurium and Bacillus cereus. All the tested bacterial strains displayed varying degrees of susceptibi...