Abstract Funding Acknowledgements Type of funding sources: None. Background Conventional right ventricular pacing induces dyssynchrony and 20% patients may need upgrade for resynchronisation therapy (CRT). Currently, left bundle branch area (LBBAP) is growing as an alternative conventional pacing, preserving function. Purpose We aimed to describe procedural characteristics a group consecutive s...

Cardiac resynchronisation therapy (CRT) using biventricular (BIV) pacing has proved its effectiveness to correct myocardial asynchrony and improve clinical status of patients with severe congestive heart failure (CHF) and widened QRS. Despite a different effect on left ventricular electrical dispersion, left univentricular (LV) pacing is able to achieve the same mechanical synchronisation as BI...

The right ventricular (RV) apex has been used as the traditional pacing site since the development of transvenous pacing in 1959. Some studies suggest that pacing the RV apex may cause an “iatrogenic” left bundle branch block and remodeling of the left ventricle and is therefore harmful. In the past decade, the need for alternate site pacing became imperative and there have been a multitude of ...

OBJECTIVES The aim of the study was to evaluate whether left ventricular (LV) mechanics are better under LV-based pacing than under right ventricular (RV) apical pacing in patients with permanent atrial fibrillation (AF) after atrioventricular junction (AVJ) ablation. BACKGROUND "Ablate and pace" is an acceptable therapy for drug-refractory AF. However, the RV apical stimulation commonly used...

Chronic rapid ventricular pacing in the dog reportedly produces a useful preparation of low-output heart failure. However, little information is available regarding cardiac changes in this preparation. Accordingly, we evaluated the effects of both short-term (3 weeks) and prolonged (2 months) rapid ventricular pacing on cardiac hemodynamics, mass, and chamber size. The effects of short-term pac...

BACKGROUND Cardiac resynchronization therapy (CRT) delivered via left ventricular (LV) endocardial pacing (ENDO-CRT) is associated with improved acute hemodynamic response compared with LV epicardial pacing (EPI-CRT). The role of cardiac anatomy and physiology in this improved response remains controversial. We used computational electrophysiological models to quantify the role of cardiac geome...

Cardiac resynchronization therapy (CRT) has been shown to improve quality-of-life, functional status, exercise capacity, and survival in patients with left ventricular systolic dysfunction, moderate to severe heart failure symptoms, and a wide QRS. Controlled, randomized CRT trials have used atrial sensing to provide atrial-synchronized biventricular pacing, but have not focused on atrial pacin...

OBJECTIVE Biventricular pacing has demonstrated improvement in cardiac function in treating congestive heart failure (CHF). Two different operative strategies (coronary sinus vs. epicardial stimulation) for left ventricular (LV) pacing were compared. METHODS Since April 1999, a total of 86 patients (pts, age: 63+/-10 years) with depressed systolic LV function (mean ejection fraction 24+/-9%),...

Cardiac resynchronization therapy (CRT) typically is attempted with biventricular pacing (BiVP). One-third of patients are nonresponders. Left-bundle (LBP) an alternative means effective CRT because it can correct the left bundle branch block. We assessed feasibility and clinical response LBP as to BiVP in CRT-indicated patients.

In this study, electrical and structural remodeling of ventricles was examined in tachycardia-induced heart failure (HF). We studied two groups of weight-matched adult male mongrel dogs: a sham-operated control group (n=5) and a pacing group (n=5) that underwent ventricular pacing at 230 bpm for 3 weeks. Clinical symptoms of congestive HF were observed in both groups. Their hemodynamic paramete...