most orthodontic practices, they present a number of challenges, not all of which are related to malocclusions. For example, the oral administration of bisphosphonates is rising dramatically in the form of anti-osteoporosis medications, especially in women. Osteonecrosis of the jaws has been associated with intravenous administration of bisphosphonates, and there are also reports of oral lesion...

Several recent reports have described "atypical" fractures of the subtrochanteric and diaphyseal femoral shaft that occur with minimal or no trauma, associated with the use of bisphosphonates. Physicians treating bone diseases with bisphosphonate need, therefore, to be aware of this potential risk and plan the prophylaxis, early diagnosis and prevention of potential consequences. We review the ...

BACKGROUND The utility of bisphosphonates in the treatment of postmenopausal osteoporosis is compromised by the requirement of frequent oral administration or complex cyclic regimens. Recognition that simplified dosing regimens and reduced frequency of administration are important factors for improving adherence to therapy has led to the development of bisphosphonates with less frequent dosing ...

INTRODUCTION Osteoporosis is an under-recognized problem threatening men. Bisphosphonates are the main treatment but their comparative efficacy is unclear for men with osteoporosis. Therefore, we performed this systematic review with network meta-analyses to summarize the evidence of comparative efficacy of bisphosphonates in men with osteoporosis. METHODS We completed network meta-analyses w...

Osteoporosis carries a high burden of illness, both for individual patients and society. In addition to substantial health care system costs, osteoporosis-associated fractures cause pain, disability, and increased risk of institutionalization. An estimated 50% of Canadian women older than 80 years of age meet diagnostic criteria for osteoporosis.1 Family physicians work with patients to prevent...

BACKGROUND This position paper addresses the prevention of bisphosphonate-associated osteonecrosis (BON) and the management of care of patients with cancer and/or osteoporosis who are receiving bisphosphonates and who have BON or are at risk of developing it. METHODS The authors reviewed the literature available on this newly described oral complication. Information of interest included bisph...