The reaction of 3-aminopyrazole (1) with 1,2-naphthoquinone-4-sulfonic acid sodium salt (2) was studied in different aqueous media. The novel pyrazolylnaphthoquinones synthesized were physical and spectroscopically characterized, including 2D NMR spectroscopy (HETCOR). The possible reaction mechanism is proposed. Introduction Quinones and naphthoquinones are widely distributed in nature and pla...

The genus Diospyros is one of the most important sources of bioactive compounds, exclusively 1,4-naphthoquinones. The following information is an attempt to cover the developments in the biology and phytochemistry of 1,4-naphthoquinones isolated from this genus, as well as the studies done and the suggested mechanisms regarding their activities. During the past 60 years, many of these agents ha...

Self-organizing molecular field analysis (SOMFA), a simple three-dimensional quantitative structure activity relationship (3D-QSAR) based cheminformatics method was used in present case to study the correlation between the molecular properties and the PTP 1B inhibitory activities of a series of 1,2-naphthoquinone that acts as selective PTP 1B inhibitors. The statistical results, cross-validated...

Aim. To develop and validate a spectrophotometric technique for quantitative determination of glibenclamide in tablets by reaction with 2,3-dichloro-1,4-naphthoquinone. Materials methods. In the study, substance pharmacopoeial purity was used, – “Maninil” 5 mg “Glibenclamid-Zdorovye” mg, 2,3-dichloro-1,4-naphthoquinone “CFA” qualification chosen as reagent, solvent dimethylformamide (DMF) “CFA”...

Vapour and particle-associated concentrations of 15 polycyclic aromatic hydrocarbons (PAH) and 11 PAH quinones have been measured in winter and summer campaigns at the rural site, Weybourne in eastern England. Concentrations of individual PAH are relatively smaller than average concentrations measured previously at urban sites in the UK. The concentrations of PAH of the air masses originating f...