The aim of this study is to estimate the frequency of personality disorders in patients with recurrent unipolar or bipolar affective disorders and the possible relationship of the categorical model with two dynamic psychopathological configurations. Forty-eight patients were studied using semi-structured interviews for assessing Axis I and Axis II disorders. We found that approximately 70% of p...

BACKGROUND Individuals with bipolar disorder present with moderate impairments in social cognition during the euthymic state. The impairment extends to theory of mind and to the perception of emotion in faces and voices, but it is unclear if emotion perception from body movements is affected. The main aim of this study was to examine if participants with bipolar disorder perform worse than heal...

BACKGROUND While nonmedical use of opioids and psychiatric disorders are prevalent in the population, little is known about the temporal ordering between nonmedical opioid use and dependence and psychiatric disorders. METHOD Data were gathered in a face-to-face survey of the United States conducted in the 2001-2002 (NESARC wave 1). Participants were household and group quarters residents aged...

n contrast to the relationship between substance abuse and bipolar disorder, the relationship between bipolar I disorder and anxiety disorders is vastly underexplored, underappreciated, and certainly understudied. This inattention is surprising in light of the fact that anxiety disorders have the highest rate of comorbidity with bipolar disorder , exceeding the comorbidity rate even of substanc...

Bipolar disorder and schizophrenia share phenotypic and genotypic features, but might differ in aspects of abnormal neurodevelopmental trajectories. We studied gyrification, a marker of early developmental pathology, in high-resolution MRI scans of 34 patients with schizophrenia, 17 euthymic bipolar I disorder patients with previous psychotic symptoms, and 34 matched healthy controls in order t...

A comparison of clinical characteristics in bipolar I disorder and antidepressantassociated mania/hypomania Objective: Although hypomania/mania during antidepressant treatment is not rare, it is often neglected by clinicians. As a result of the recent developments in this topic, bipolarity is now accepted as a wide spectrum. Forty percent of the patients with bipolar disorder have been misdiagn...

BACKGROUND The fifth version of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) opted to retain existing diagnostic boundaries between bipolar I disorder, schizoaffective disorder, and schizophrenia. The debate preceding this decision focused on understanding the biologic basis of these major mental illnesses. Evidence from genetics, neuroscience, and pharmacotherapeutics info...

BACKGROUND Subtle abnormalities in frontal white matter have been reported in bipolar disorder. AIMS To assess whether impaired integrity of white matter tracts is associated with bipolar disorder and genetic liability for the disorder. METHOD A total of 19 patients with psychotic bipolar I disorder from multiply affected families, 21 unaffected first-degree relatives and 18 comparison indi...