نتایج جستجو برای: bipolar disorder cohort risk factor suicide
تعداد نتایج: 2299814 فیلتر نتایج به سال:
Bipolar disorder, formerly known as manic-depressive disorder, consists of often recurrent and severe mood episodes. Roughly 1% of children are diagnosed with bipolar disorder; the prevalence doubles in adulthood. The intense mood swings and periods of depression contribute to the significant morbidity and mortality associated with this disorder, which ranks seventh among worldwide causes of no...
BACKGROUND Bipolar disorder is a highly heritable polygenic disorder. Recent enrichment analyses suggest that there may be true risk variants for bipolar disorder in the expression quantitative trait loci (eQTL) in the brain. AIMS We sought to assess the impact of eQTL variants on bipolar disorder risk by combining data from both bipolar disorder genome-wide association studies (GWAS) and bra...
BACKGROUND Anecdotal and biographical reports suggest that bipolar disorder may be associated with high IQ or creativity, but evidence for any such connection is weak. AIMS To investigate possible associations between scholastic achievement and later bipolar disorder, using prospective data, in a whole-population cohort study. METHOD Using individual school grades from all individuals finis...
The aims of the present study were to examine clinical, personality, and sociodemographic predictors of suicide risk in a sample of inpatients affected by major affective disorders. The participants were 74 inpatients affected by major depressive disorder or bipolar disorder-I. Patients completed a semi-structured interview, the Beck Hopelessness Scale, the Aggression Questionnaire, the Barratt...
Post-mortem studies document alterations in the central noradrenergic system in suicide. However, studies of non-fatal suicide attempts have, thus far, found no consistent relationship to the noradrenaline metabolite 3-methoxy-4-hydroxphenylglycol (MHPG) in cerebrospinal fluid (CSF). We therefore conducted a prospective study of CSF MHPG and suicidal acts in major depression and bipolar depress...
BACKGROUND Deficits in cognitive functioning have been associated with bipolar disorder during episodes of depression and mania, as well as during periods of symptomatic remission. Separate evidence suggests that patients may lack awareness of these deficits and may even be overly confident with self-appraisals. The extent to which these separately or together represent prodromes of the disorde...
BACKGROUND Irritable bowel syndrome (IBS) is the most common functional gastrointestinal (GI) disorder observed in patients who visit general practitioners for GI-related complaints. A high prevalence of psychiatric comorbidities, particularly anxiety and depressive disorders, has been reported in patients with IBS. However, a clear temporal relationship between IBS and psychiatric disorders ha...
Bipolar depression is often refractory to treatment and is frequently associated with anxiety symptoms and elevated suicide risk. There is a great need for adjunctive psychotherapeutic interventions. Treatments with effectiveness for depressive and anxiety symptoms as well as suicide-related thoughts and behaviors would be particularly beneficial. Mindfulness-based interventions hold promise, a...
Risk factors for suicide among children and youths with bipolar spectrum and early bipolar disorder.
BACKGROUND People with severe mental illness have a higher risk than others of some physical diseases. The risk of pneumococcal disease in people with mental disorders is unknown. This is potentially important because vaccines against the pneumococcus are available. METHODS We used two datasets of linked hospital admission and death records, the Oxford Record Linkage Study and all-England lin...
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