In the present work, we report the first bionanocomposite material formed by otoliths/ collagen/ bacterial cellulose (BC) networks (OCBC). This biomaterial is an osteoinductor or be, stimulates the bone regeneration, enabling bigger migration of the cells for formation of the bone tissue regeneration mainly because nanotolith are rich in minerals considered essential to the bone mineralization ...

Stem Cell Lineage Fate Highly accurate, efficient, and convenient evaluation for biomaterial-induced stem cell lineage fate is pivotal regenerative biomaterials research. In article number 2210637, Binbin Lai, Xuehui Zhang, Xuliang Deng, co-workers report MeD-P, a machine-learning-supported intelligent model, predicting human mesenchymal cell–biomaterial interaction based on RNA-seq data. This ...

Validation of transendocardial injection as a method for delivering therapeutic agents to the diseased heart is increasing. Puncture heart biopsies should re-emerge as a possible alternative method to allow access to the myocardium and implantable biomaterial for cell therapy. Therefore, this work aims to present a percutaneous puncture device for biopsy and intramyocardial biomaterial injectio...

Materials used for biomedical applications cover a wide spectrum and must exhibit specific properties. The most important property of materials used for fabricating implants is biocompatibility, followed by corrosion resistance. The main metallic biomaterials are stainless steels, cobalt alloy, and titanium and titanium alloys. Stainless steel was the first metallic biomaterial used successfull...

Cancer immunotherapy is becoming a standard approach to treat many cancers. However, shortcomings of current methods limit therapeutic benefit in many patients. Rationally designed biomaterial strategies to deliver immune modulatory drugs can potentially show improved safety profiles, while providing multifunctional and spatiotemporally controlled signals to immune cells to improve their anti-c...

We studied a new injectable biomaterial for bone and dental surgery consisting of a hydrophilic polymer as matrix and bioactive calcium phosphate (CaP) ceramics as fillers. This material is composed of complex fluids whose flow is determined by the laws of rheology. We investigated the macromolecular effects on this composite in a tube. The stability of the polymer and the mixture is essential ...

1 Part 1: Covalent immobilisation of IGF-1 on PECVD-Si-Ti for orthopaedic biomaterial applications 1.

Background: With the present study we introduce a novel and simple biomaterial able to induce regeneration of bone. We theorized that nourishing a bone defect with calcium and with a large amount of activated platelets may initiate a series of biological processes that culminate in bone regeneration. Thus, we engineered CS-Platelet, a biomaterial based on the combination of Calcium Sulfate and ...

Introduction Myocardial tissue regeneration is an emerging field of interest, aiming to reintroduce cardiac tissue and/or enhance self-repair of the infarct after myocardial infarction (MI). We developed a novel acellular injectable alginate biomaterial by utilizing the ability of alginate-sulfate to affinity-bind and present heparin-binding proteins. We hypothesized that such affinitybinding b...