Vitamin C, an antioxidant substance soluble in water, can react with amino groups of proteins to form schiff bases. As diabetes leads to glycation of various protein which has effect on structure and biochemical activity of them, the inhibition of this process seems very vital. For several years researches in this field have done their best to recognize the antidiabetics compounds. The aim of t...

Abstract We study a free-boundary fluid–structure interaction problem with growth, which arises from the plaque formation in blood vessels. The fluid is described by incompressible Navier–Stokes equations, while structure considered as viscoelastic neo-Hookean material. Moreover, growth due to biochemical process taken into account. Applying maximal regularity theory linearization of along defo...

Vitamin C, an antioxidant substance soluble in water, can react with amino groups of proteins to form schiff bases. As diabetes leads to glycation of various protein which has effect on structure and biochemical activity of them, the inhibition of this process seems very vital. For several years researches in this field have done their best to recognize the antidiabetics compounds. The aim of t...

the use of quantitative structure–activity relationships, since its advent, has becomeincreasingly helpful in understanding many aspects of biochemical interactions in drug research.this approach was utilized to explain the relationship of structure with biological activity ofantibacterial. for the development of new fungicides against, the quantitative structural–activityrelationship (qsar) an...

Each of the major classes of clinically useful antibiotics can cause neph­ rotoxicity. Major differences exist among classes, and these are reviewed with regard to the frequency of occurrence of nephrotoxicity, the direct or indirect toxic effects of the drugs, their site(s) of action within the kidney, current views of their pathophysiological effects and observations which provide clues to th...

CyanoPhyChe is a user friendly database that one can browse through for physico-chemical properties, structure and biochemical pathway information of cyanobacterial proteins. We downloaded all the protein sequences from the cyanobacterial genome database for calculating the physico-chemical properties, such as molecular weight, net charge of protein, isoelectric point, molar extinction coeffici...

Biochemical chemistry, as one of the core courses in medical education, involves structure, function, metabolism, and other key contents human biomolecules, which is great significance cultivating students' scientific literacy clinical practice ability. However, traditional teaching biochemical chemistry often based on independent chemical concepts lacks organic integration with basic knowledge...

Hormone level differences are generally accepted as the primary cause for sexual dimorphism in animal and human development. Levels of low molecular weight metabolites also differ between men and women in circulating amino acids, lipids and carbohydrates and within brain tissue. While investigating the metabolism of blue crab tissues using Phosphorus-31 Nuclear Magnetic Resonance, we discovered...

PIWI-interacting RNAs (piRNAs) protect the genome from transposons in animal gonads. Maelstrom (Mael) is an evolutionarily conserved protein, composed of a high-mobility group (HMG) domain and a MAEL domain, and is essential for piRNA-mediated transcriptional transposon silencing in various species, such as Drosophila and mice. However, its structure and biochemical function have remained elusi...

Normal human plasma contains a complex of two proteins that are important in hemostasis and coagulation. The factor VIII procoagulant protein (antihemophilic factor) and the factor VIII-related protein (von Willebrand factor) are under separate genetic control, have distinct biochemical properties, and have unique and essential physiologic properties. While the nature of their interaction and t...