نتایج جستجو برای: bioavailable

تعداد نتایج: 3626  

Journal: :Bone 2012
Margaret L Gourlay Bonny L Specker Chenxi Li Catherine A Hammett-Stabler Jordan B Renner Janet E Rubin

PURPOSE Increased follicle-stimulating hormone (FSH) has been associated with lower bone mineral density (BMD) in animal models and longitudinal studies of women, but a direct effect has not been demonstrated. METHODS We tested associations between FSH, non-bone body composition measures and BMD in 94 younger (aged 50 to 64 years) postmenopausal women without current use of hormone therapy, a...

Journal: :Environmental Health Perspectives 1997
D L Costa K L Dreher

Many epidemiologic reports associate ambient levels of particulate matter (PM) with human mortality and morbidity, particularly in people with preexisting cardiopulmonary disease (e.g., chronic obstructive pulmonary disease, infection, asthma). Because much ambient PM is derived from combustion sources, we tested the hypothesis that the health effects of PM arise from anthropogenic PM that cont...

2006
Tracy N. Wiegner Sybil P. Seitzinger Patricia M. Glibert Deborah A. Bronk

Dissolved organic nitrogen (DON) and carbon (DOC) often dominate the dissolved nitrogen and organic carbon fluxes from rivers, yet they are not considered to affect coastal water quality because of their assumed refractory nature. The objective of this study was to quantify DON and DOC bioavailability to bacteria in 9 rivers on the east coast of the United States during a 6 d dark bioassay expe...

Journal: :Environmental science & technology 2013
Yuanrong Zhu Fengchang Wu Zhongqi He Jianyang Guo Xiaoxia Qu Fazhi Xie John P Giesy Haiqing Liao Fei Guo

The role of sediment-bound organic phosphorus (Po) on lake eutrophication was studied using sequential extraction and enzymatic hydrolysis by collecting sediments from Dianchi Lake, China. Bioavailable Po species including labile monoester P, diester P, and phytate-like P were identified in the sequential extractions by H2O, NaHCO3, and NaOH. For the H2O-Po, 36.7% (average) was labile monoester...

Journal: :ACS medicinal chemistry letters 2011
Chris P Miller Maysoun Shomali C Richard Lyttle Louis St L O'Dea Hillary Herendeen Kyla Gallacher Dottie Paquin Dennis R Compton Bishwabhusan Sahoo Sean A Kerrigan Matthew S Burge Michael Nickels Jennifer L Green John A Katzenellenbogen Alexei Tchesnokov Gary Hattersley

This report describes the discovery of RAD140, a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). The characterization of RAD140 in several preclinical models of anabolic androgen action is also described.

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