this study was done to assess bioequivalence between test and reference formulations of escitalopram oxalate 20 mg in healthy indian male subjects. this single-dose, randomized, open-label, 2-period crossover study was carried out in 12 healthy indian male volunteers aged 18 to 55 years under fasting conditions with a wash out of 14 days.  the subjects were randomly assigned to receive the test...

knowledge of the probable origin and behaviour of arsenic certainly gives valuable insights into the potential for transfer in the environment and of the risks involved in mining sites. sequential extraction analyses are common experiments often used to study the origin and behaviour of potentially toxic elements. the method, however, presents some deficiencies, including labor-intensive proced...

For an accurate risk assessment of sites contaminated by trace elements (TE), measurements of bioavailability must be performed. This is routinely achieved using the standardized 0.01M CaCl2 method. However, the suitability of chemical extractions as proxies of bioavailability is questionable. We analyzed the correlations between chemically estimated TE bioavailability and TE actually accumulat...

Introduction Consumption of low glycemic-index (LGI) foods has been shown to attenuate blood glucose response during the postprandial period immediately following a meal. In addition, positive metabolic effects can persist well beyond this period. One of these extended effects, known as the “second-meal effect,” is the positive effect of the bioavailability of glucose on the glucose tolerance o...

A critically evaluated database of human oral bioavailability for 768 chemical compounds is described in this study (http://modem.ucsd.edu/adme), which provides the scientific community a publicly available and reliable source for developing predictive models of human oral bioavailability. The correlations between several important molecular properties and human oral bioavailability were invest...

Peptides in general hold much promise as a major ingredient in novel supramolecular assemblies. They may become essential in vaccine design, antimicrobial chemotherapy, cancer immunotherapy, food preservation, organs transplants, design of novel materials for dentistry, formulations against diabetes and other important strategical applications. This review discusses how novel formulations may i...

Resveratrol has proven potential natural antioxidant, non-flavanoid polyphenolic compound, but it limitations such as low water solubility, which substantially restricts oral bioavailability. To enhance bioavailability and antioxidant of resveratrol by fabricating the encapsulated eudragit® E100 based polymeric nano-delivery system. Resveratrol-encapsulated nanoparticles (Resveratrol-polymeric ...

The migration and transformation of soil heavy metals around mines is a hot issue global concern. In order to evaluate the potential risk transformation, investigation surface sample collection were conducted Pb-Zn mine. Contents fourteen in four different fields analyzed. And speciation As, Cd, Cr, Cu, Ni, Pb Zn was detected by sequential extraction procedures. Then, characteristics them are d...

The pharmaceutical industries are more interested in development of novel drug delivery system to overcome the disadvantages traditional system. Now a days, fungal infections increasing worldwide. Hence demand dosage form is increased with improved therapeutic effect and minimum side effect. main aim this study was develop griseofulvin loaded ß -cyclodextrin based nanosponges for improving diss...

Nanoemulsion is an alternative and promising approach to overcome insolubility and bioavailability problems of bioactive compounds. In this study, the sonication parameter for preparing nanoemulsions with high α- tocopherol and linolenic acid content were optimized by using response surface methodology and their stability were evaluated during 2 months’ storage. The response surface analysis re...