Groups of rats were fed a diet of the purified type which was supplemented by dl-ethionine to produce pancreatic damage. It was shown that animals with pancreatic damage absorbed more iron from the gastrointestinal tract than control animals without pancreatic damage. When iron was added to the diet the animals with pancreatic damage absorbed even greater quantities of iron. These findings in r...

Antibody to DNA was measured before and after treatment of systemic lupus erythematosus (SLE) sera with bovine pancreatic deoxyribonuclease (DNase I). In 11 of 15 cases of SLE with active renal disease there was a significant increase in DNA-binding after DNase digestion, while no such increase was noted in inactive SLE, normal controls or in patients with nonlupus renal disease. The significan...

BACKGROUND Steatorrhea following major pancreatic resection can be difficult to control, requiring high doses of pancreatic enzyme supplements. The aim of this study was to demonstrate equivalent efficacy of high-dose and standard-dose pancreatin in treating steatorrhea after pancreatectomy. METHODS A randomized, double-blind, crossover study was conducted with a 2-wk run-in period for stabil...

The excretion of intravenously injected labeled zinc into pancreatic juice, duodenal juice, and bile of the dog was investigated. The use of the radioactive isotope permitted the injection of minute amounts of zinc, amounts that were negligible when compared with the total amount of zinc already present in the animal. 1. A large proportion of the injected Zn(65) was eliminated by way of the ext...

We studied the effect of 2 different parenteral regimens upon gastrin, motilin and pancreatic polypeptide (PP) levels in infants. In 15 children, aged 1-25 months, plasma peptide levels were measured by radioimmunoassay in the fasting state and after a 2-h infusion of either a mixture of amino acids, glucose and lipids (A) or a mixture of amino acids and glucose (B) only. Wide interindividual f...

RATIONALE A widely applicable model of emphysema that allows efficient and sensitive quantification of injury is needed to compare potential therapies. OBJECTIVES To establish such a model, we studied the relationship between elastase dose and the severity of emphysema in female C57BL/6J mice. We compared alveolar fractal box dimension (D(B)), a new measure which is an assessment of the compl...

1964; Salek et al., 1965). Unfortunately our patient was too ill for studies of pancreatic function immediately before and after radiotherapy, but irradiation clearly resulted in a rapid inhibition of exocrine pancreatic secretion. The effect was transient: 12 weeks later pancreatic function was only slightly impaired. Though pancreatic ascites has resolved after conservative management and aft...

We have compared the concentrations and total outputs of trypsin, amylase, and lipase secreted into the duodenum during secretin pancreozymin and Lundh Borgstrom tests in order to assess the relative intensity of pancreatic stimulation provided by these means. The mean concentration of trypsin, and the mean 10 minute total output of trypsin, amylase, and lipase after the meal (though less than ...

In the literature, CC presenting with PH has not been addressed adequately and there is a paucity of literature on CC complicated by PH. Gastrointestinal bleeding, splenomegaly or incidental discovery of esophageal varices led to the diagnosis of associated PH. Excision of CC and bilio-enteric bypass may not be feasible in those patients as there is a formation of massive collaterals in the reg...

Many studies on ribonuclease would benefit if reproducible, purified samples of the enzyme were readily available. The present report summarizes experiments on the preparation and storage of chromatographically purified bovine pancreatic ribonuclease A.’ Much of the earlier work on ribonuclease was done with a single, large, commercial batch of material (Armour Lot 381059) which was isolated fr...