Glyoxal, methylglyoxal and other physiological alpha-oxoaldehydes are formed by the lipid peroxidation, glycation and degradation of glycolytic intermediates. They are detoxified enzymically by the glyoxalase system. To investigate the physiological function of glyoxalase I in parasitic organisms, the cDNA for glyoxalase I from the filarial nematode Onchocerca volvulus (designated Ov-GloI) has ...

The expression of appropriate ensembles of ionic channels is necessary for the differentiation and normal function of vertebrate neurons. Cell-cell interactions may regulate the expression and properties of ionic channels in embryonic neurons. Previous studies have shown that the expression of A-type K+ channels (IA) and Ca2+-activated K+ channels (lK[Ca]) is abnormal in chick ciliary ganglion ...

Oncolytic viruses (OV) were first observed in early clinical studies in patients with malignancies where tumour regressions were observed to coincide with viral infections or with live virus vaccinations. Since these early reports, studies using OV have progressed from anecdotal and controlled infections to specifically selecting or genetically modifying viruses for cancer treatment. OV are int...

Bessel beams are of great interest due to their unique non-diffractive properties. Using a conical prism or an objective paired with an annular aperture are two typical approaches to generating zeroth order Bessel beams. However, the former approach has a limited numerical aperture (NA), and the latter suffers from low efficiency since most of the incident light is blocked by the aperture. Furt...

Suppose that d ∈ N and p > 0. In this paper, we study the generalized Bessel functions for the surface {v ∈ Rd : |v|p = 1}, introduced by D.St.P. Richards. We derive a recurrence relation for these functions and utilize a series representation to relate them to the classical symmetric functions. These generalized Bessel functions are symmetric with respect to the action of the hyperoctahedral g...

In this paper we complete and improve the study of the simulation of the hitting times of some given boundaries for Bessel processes. These problems are of great interest in many application fields as finance and neurosciences. In a previous work [9], the authors introduced a new method for the simulation of hitting times for Bessel processes with integer dimension. The method, called walk on m...

A recently reported chitinase gene, expressed in the infective, third-stage (L3) larvae of the human filarial parasite Onchocerca volvulus, belongs to the family 18 glycosyl hydrolases and has been designated Ov-chi-1. The gene product of Ov-chi-1 is chitinolytic. Allosamidin ablates activity of the native enzyme in a dose-dependent manner but did not significantly inhibit the moulting of L3 la...

Functional Near Infrared Spectroscopy (fNIRS) can non-invasively capture dynamic cognitive activation and underlying physiological processes by measuring changes in oxy- and deoxy-hemoglobin levels, correlated to brain activation. It is a portable, inexpensive and user-friendly device which is easily adapted to the outpatient setting for the assessment of cognitive functions after Traumatic Bra...

The aim of this study was to evaluate the oxidative stress in ovaries and corpus luteum (CL) Bos taurus indicus females oxidant effect CL ovarian tissues regions near, intermediate, or distant from it. Ovaries (n=12) Nelore heifers (n=6) were collected a slaughterhouse fragmented. Experiment 1, each ovary obtained three fragments, resulting 18 fragments with (OV+CL) another without (OV-CL). Thr...