A novel series of indolizinebutyric acids with various benzoyl substituents was synthesized to develop nonsteroidal inhibitors of steroid 5alpha-reductase, and the structure-activity relationships in this series were studied. We previously reported the structure-activity relationships in a series of indolebutyric acids as well as the discovery of the novel nonsteroidal 5alpha-reductase inhibito...

The conformation of the N-H bond in the structure of the title compound, C(14)H(12)ClNO, is anti to the meta-chloro substituent in the aniline ring, while the C=O bond is syn to the ortho-methyl substituent in the benzoyl ring. The conformations of the N-H and C=O bonds are anti to each other, similar to those observed in 2-methyl-N-(3-methyl-phen-yl)benzamide (N3MP2MBA). The -NHC(=O)- group ma...

A series of five-membered heterocyclic rings were synthesized by the reaction between benzoyl chloride and various chlolro-nitro-benzoyl chlorides and semi carbazide to form (C1-C7) compounds and was tested for their anti-inflammatory activity determined by rat-paw-oedema method. All the synthesis compounds have been characterized by 1HNMR, IR and Mass spectral data. The compounds were purified...

In this paper, quantum chemical parameters at density functional theory (DFT) B3LYP/6-31G** (d,p) level of theory were calculated for three organic corrosion inhibitors [N-benzoyl-N-(p-aminophenyl) thiourea, N-benzoyl-N-(thiazole) thiourea and N-acetyl-N-(dibenzyl) thiourea. The calculated molecular descriptors such as the HOMO, LUMO, dipole moment, chemical potential (μ), chemical hardness (ղ)...

In the crystal structure of the title compound, C(13)H(10)ClNO(3)S, the conformation of the of the N-H bond in the C-SO(2)-NH-C(O) segment is anti to the C=O bond. The dihedral angle between the two benzene rings is 73.3 (1)°. In the crystal, inversion dimers linked by pairs of N-H⋯O hydrogen bonds occur.

In the title compound, C(14)H(10)N(2)O, the benzoyl ring and benzimidazole ring system are aligned at a dihedral angle of 50.2 (2)°. In the crystal, inter-molecular N-H⋯N hydrogen bonds between adjacent imidazole groups generate supra-molecular C(4) chains running along the b axis.

The title compound, C(17)H(15)NO(2), was synthesized by reaction of 1,2-dibromo-ethane with 1-benzoyl-N-phenyl-cyclo-propane-carboxamide and K(2)CO(3) in dimethyl-formamide. The mol-ecule exhibits a V-shaped conformation in the crystal with a dihedral angle of 88.7 (3)° between the two benzene rings. Pairs of N-H⋯O hydrogen bonds link the mol-ecules into dimers about centres of inversion.