The title compound, C(19)H(10)F(5)NO(2), was synthesized by the 1:1 condensation of 2-methyl-8-hydroxy-quinaldine with penta-fluoro-benzaldehyde. It crystallizes with two almost identical mol-ecules in the asymmetric unit. The penta-fluoro-benzene ring is essentially coplanar with the quinoline ring, forming dihedral angles of 2.49 (17) and 8.72 (16)° in the two mol-ecules.

Benzaldehyde lyase from Pseudomonas fluorescens Biovar I. (BAL, EC 4.1.2.38) is a versatile catalyst for the organic synthesis of chiral α-hydroxy ketones. To allow fast assessment of enzyme activity, a direct spectrophotometric assay is desirable. Here, a new robust and easy-to-handle assay based on UV absorption is presented. The assay developed is based on the ligation of the α-hydroxy keton...

The title compound, C(15)H(13)ClN(2)O(2)·CH(4)O, consists of a 4-chloro-N'-(4-meth-oxy-benzyl-idene)benzohydrazide (CMB) mol-ecule and a methanol mol-ecule of crystallization. It was obtained by the condensation of 4-meth-oxy-benzaldehyde with 4-chloro-benzohydrazide. In the CMB mol-ecule, the dihedral angle between the two benzene rings is 50.1 (3)°. The methanol mol-ecule is linked to the CMB...

The Cannizzaro reaction ("RX C") and the benzoin reaction ("RX B") were investigated by density functional theory calculations. Reaction models (benzaldehyde)2 + X(-) + (H2O)n [for X(-) = OH(-) (RX C) n = 8, and for X(-) = CN(-) (RX B) n = 8 or n = 14] were adopted. Three transition states (TSs) were obtained for RX C, and the rate-determining step was confirmed to be the hydride shift. The sin...

The mol-ecule of the title Schiff base compound, C(16)H(15)N(3)O(5), obtained from a condensation reaction of 4-acet-oxy-3-meth-oxy-benzaldehyde and 4-nitro-phenyl-hydrazine, adopts an E geometry with respect to the C=N double bond. The mol-ecule is roughly planar, with the two benzene rings twisted slightly with respect to each other by a dihedral angle of 6.90 (9)°. In the crystal, inter-mole...

In the title compound, C(10)H(13)NO(2), synthesized by the reaction of 2-hy-droxy-3-eth-oxy-benzaldehyde with methyl-amine, there is an an intra-molecular O-H⋯N hydrogen bond involving the hy-droxy substituent and the amino N atom. In the crystal, mol-ecules form inversion dimers connected by pairs of C-H⋯O hydrogen bonds.

The title compound, C(18)H(20)O(4), was synthesized by a Wittig-Horner reaction of diethyl 3,4-dimeth-oxy-benzyl-phosphate and 3,5-dimeth-oxy-benzaldehyde. In the crystal, the dihedral angle between the two aromatic rings is 2.47 (12)°. All the meth-oxy groups are almost coplanar with the aromatic ring to which they are attached [C-C-O-C torsion angles = -2.8 (3), -5.2 (4), -176.3 (2) and -178....

The title compound, C(20)H(26)N(4)O(2)·CH(3)OH, was prepared by the reaction of 4-diethyl-amino-2-hy-droxy-benzaldehyde with 4-(dimethyl-amino)-benzohydrazide. The dihedral angle between the two benzene rings is 13.6 (3)° and an intra-molecular O-H⋯N hydrogen bond generates an S(6) ring. In the crystal, the hydrazone and methanol mol-ecules are linked through inter-molecular O-H⋯O and N-H⋯O hyd...

An enantioselective organocatalytic strategy, combining Brønsted base and N-heterocyclic carbene catalysis in a unique manner, is demonstrated for a concise construction of the privileged cyclopenta[b] benzofuran scaffold, present in many bioactive compounds having both academic and commercial interests. The reaction concept relies on an intramolecular one-pot double cyclization involving a cyc...

A resolution equation for EKC was developed starting from the resolution equation for electrophoresis. The equation was used to predict the influence of the migration window and partitioning on resolution in EKC. It is theoretically shown that the migration window can have a dramatic effect on resolution in EKC. Using a novel chiral surfactant, the influence of the migration window and partitio...