To-day few clinicians doubt the efficacy of penicillin as the sole curative agent in the treatment of syphilis, and the wide range of arsenical and bismuth preparations at one time available have virtually disappeared from the pharmaceutical market. The first few sailors to be given penicillin for syphilis were treated by Mahoney, Arnold, and Harris (1943), which event was followed by numerous ...

Introduction The treatment of gonorrhoea in Denmark is as yet no serious therapeutic problem, as the majority of gonococcal infections can be cured by penicillin. Nevertheless, in an increasing number ofcases a higher dosage of penicillin is required than was the case just a few years ago. At the Dermato-venereological Department of the University Hospital, a single treatment dose of 300,000 un...

Since January 1996, and over a 3-year time span, a significant spread of serotype 6B multidrug-resistant (MDR) pneumococci, susceptible to penicillin and resistant to erythromycin, clindamycin, tetracycline, chloramphenicol, and trimethoprim-sulfamethoxazole, was noted in young carriers living in central and southern Greece. Using restriction fragment end labeling and penicillin binding protein...

c Abstract: Background: The development of resistance to penicillin in Viridans Group Streptococci (VGS) during therapy has been reported. However, the in vitro development of resistance to penicillin or other antimicrobial agents in VGS is mostly overlooked and rarely reported. Aim & Objectives: To induce in vitro resistance to penicillin in VGS and to study its effect on susceptibility patter...

Eight recent isolates of Neisseria gonorrhoeae with high-level non-beta-lactamase-mediated penicillin resistance were investigated. The penicillin-binding proteins of these strains were found to have reduced affinity for radiolabeled penicillin. Testing for known resistance genes showed that these were present in the resistant isolates. Genetic transformation was used to construct strains with ...

Penicillin sensitivities of gonococci isolated from a peripheral health district were observed during 1977-80 by determining the minimum inhibitory concentrations (MIC) of penicillin. During the same period, outcome of penicillin treatment in patients with gonorrhoea was also observed and recorded. Penicillin resistance, as defined, was found in 19-3% strains in these years, but there were year...

The recent emergence of group B streptococcal isolates exhibiting increased penicillin MICs at the Funabashi Municipal Medical Center and other hospitals in Japan prompted a comparative analysis of the penicillin-binding proteins (PBPs) from those strains with the PBPs from penicillin-susceptible strains comprising four neonatal invasive strains isolated from 1976 to 1988 and two recent isolate...

OBJECTIVES To determine whether the transcriptional regulator Rgg contributes to penicillin-induced killing of Streptococcus pyogenes by altering a regulatory response to penicillin. METHODS Penicillin-induced killing of a wild-type and isogenic rgg mutant strain was assessed in broth and solid media and in the presence of cerulenin, which inhibits fatty acid biosynthesis (FAB). Proteins from...

Cephalosporin, along with penicillin, are among the least harmful antibiotics. It is widely prescribed for common infections such as bronchitis, otitis media, pneumonia and cellulitis. A contraindication this agent a history of penicillin allergy, due to possible cross-reactions hypersensitivity cephalosporin. Hypersensitivity reactions can occur in any mode administration almost all cephalospo...

Ceftaroline is a new cephalosporin with bactericidal activity against resistant Gram-positive organisms, including methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-resistant Streptococcus pneumoniae, as well as common Gram-negative organisms. This study tested the prodrug, ceftaroline fosamil, against a penicillin-sensitive and a penicillin-resistant strain of S. pneumoniae in ...