We demonstrate that Caenorhabditis elegans is able to form an association between the presence of the odorant benzaldehyde and the food content of its environment. When exposed to 100% benzaldehyde for 1 h in the absence of food the naive attractive response is reduced, and we have found that this olfactory adaptation is attenuated by the presence of food. Contrary to nonassociative (single sti...

Vanillin is a well-known food and cosmetic additive and has antioxidant and antimutagenic properties. It has also been suggested to have antifungal activity against major human pathogenic fungi, although it is not very effective. In this study, the antifungal activities of vanillin and 33 vanillin derivatives against the human fungal pathogen Cryptococcus neoformans, the main pathogen of crypto...

The conversion of benzaldehyde to optically active L-phenylacetyl carbinol by yeast fermentation is a key step in the manufacture of L-ephedrine. ’ Typical fermentation raw materials are molasses, which provides a source of hexoses for glycolysis, and benzaldehyde. L-phenylacetyl carbinol formation is catalyzed by the pyruvate decarboxylase complex.’ In the carboligase reaction, pyruvate is dec...

A simple, rapid, precise and accurate HPLC – UV procedure has been developed to determine benzaldehyde, the toxic oxidation product of the widely used preservative and Co – solvent, benzyl alcohol, in injectable formulations. Benzaldehyde as a main potential impurity of benzyl alcohol may cause many toxic effects such as neurotoxicity, hypersensitivity in human and fatal toxic syndrome in prema...

A series of 5-oxohexannitrile derivatives IIa-d was prepared by react ion of acry lonitrile with ketones Ia-d. On the other hand, semicarbazone derivatives IVa-d were obtained upon reaction of IIa-d with semicarbazide. Hydrolysis and esterification in one step reaction of δ-ketonitrile IIa-d resulted in the formation of the corresponding δ-ketoesters Va-d. The δ-ketoesters Va-d is readily cycli...

A rapid and sensitive method has been developed for the determination of benzaldehyde, a toxic oxidation product of the widely used preservative and co-solvent benzyl alcohol in injectable formulations of non-steroidal anti-inflammatory drugs, diclofenac, vitamin B-complex and Voltaren injection solutions by using dispersive liquid-liquid microextraction followed by gas chromatography. This met...