Conjunctival tumors are one of the most frequent of the eye and adnexa. They comprise a large variety of conditions, from benign lesions such as nevus or papilloma, to malignant lesions such as epidermoid carcinoma or melanoma which may threaten visual function and the life of the patient. They can arise from any cellular component, but the most frequent are of epithelial and melanocytic origin...

Please cite this article as: Vázquez-Osorio I. Coexistencia de 2 fenómenos: Sutton y Meyerson. Actas Dermosifiliogr. 2017;108:671. ∗ Corresponding author. E-mail address: [email protected] (I. Vázquez-Osorio). Dermatologic examination revealed a brownish oval lesion measuring 1 cm in diameter, with a desquamating erythematous surface and a peripheral hypopigmented halo of 4 mm (Fig. 1). The Me...

Melanoma is difficult to treat when it has metastasized. Discrimination between melanoma and benign nevi in melanocytic lesions is crucial for identifying melanomas and consequently improving melanoma treatment and prognosis. The chromosome segregation 1-like (CSE1L) protein has been implicated in cancer progression and is regulated by phosphorylation by extracellular signal-regulated kinase 1/...

BACKGROUND Insulin-like growth factor-II mRNA-binding protein 3 (IMP-3 ), a member of the insulin-like growth factor mRNA-binding protein family, is expressed in several human malignancies, including melanomas. However, the expression of IMP-3 has not been explored in melanoma in situ, various histologic subtypes of invasive melanomas and atypical Spitz tumors. METHODS IMP-3 immunostain was p...

BACKGROUND Although plastic surgeons daily encounter various facial tumors in the field, reports limited on face are scarce. In our study, we want to provide basic epidemiologic data to help clinicians to decide the proper management for their patients. METHODS We retrospectively reviewed the medical records of patients including age and gender, location and size of the tumor, histopathologic...

OBJECTIVE To evaluate the role of immunohistochemical methods in the diagnosis of benign and malignant conjunctival melanocytic proliferations. DESIGN Retrospective immunohistopathologic study. METHODS Paraffin-embedded tissue sections from 20 conjunctival nevi and 15 invasive melanomas were immunoreacted with antibodies against cellular antigens S-100 protein, MART-1, HMB-45, CD-45, and Ki...

OBJECTIVES To evaluate the frequency of misclassifications of equivocal pigmented lesions according to the first step of the dermatoscopic 2-step algorithm. PATIENTS AND METHODS 707 consecutive cases from 553 patients of central Europe and Australia were included in the study. Dermatoscopic images were evaluated in a blinded fashion for the presence of features described in the 2-step algorit...

In this paper we propose a machine learning approach to classify melanocytic lesions in malignant and benign from dermatoscopic images. The image database is composed of 433 benign lesions and 80 malignant melanoma. After an image pre-processing stage that includes hair removal filtering, each image is automatically segmented using well known image segmentation algorithms. Then, each lesion is ...