نتایج جستجو برای: benign cortical epilepsy
تعداد نتایج: 229833 فیلتر نتایج به سال:
Commentary The mammalian target of rapamycin (mTOR) is a ubiquitous protein kinase that has received extensive attention in recent years as a potential mediator of epilepsy. mTOR, particularly a specific complex of proteins called mTORC1, regulates numerous cellular and physiologic functions, including protein synthesis , cell growth, proliferation, autophagy, and metabolism. Abnormal regulatio...
Focal cortical dysplasias are common malformations of cerebral cortical development and are highly associated with medically intractable epilepsy. They have been classified into neuropathological subtypes (type Ia, Ib, IIa, IIb, and III) based on the severity of cytoarchitectural disruption--tangential or radial dispersion, or loss of laminar structure--and the presence of unique cells types su...
The iron-induced model of post-traumatic chronic focal epilepsy in rats was studied by depth-electrode mapping to investigate the spread of epileptiform activity into subcortical brain structures after its onset in the cortical epileptic focus. Electrical seizure activity was recorded in the hippocampal CA1 and CA3 areas, amygdala and caudate-putamen, in rats with iron-induced chronic cortical ...
Migraine and epilepsy are comorbid episodic disorders that have common pathophysiologic mechanisms. Migraine attacks, like epileptic seizures, may be triggered by excessive neocortical cellular excitability; in migraine, however, the hyperexcitability is believed to transition to cortical spreading depression rather than to the hypersynchronous activity that characterizes seizures. Some forms o...
Objectives: The discovery of cortical spreading depression 80 years ago by Leão was intimately connected to epilepsy research. In our studies we found that monitoring brain hemodynamics, metabolic ionic and electrical activities are very similar in the two pathophysiological events. Here presenting coupling between while mitochondrial nicotinamide adenine dinucleotide-NADH together with other p...
PURPOSE PRRT2 mutations were recently identified in benign familial infantile epilepsy (BFIE) and infantile convulsions with paroxysmal choreoathetosis (ICCA) but no abnormalities have so far been identified in their phenotypically similar seizure disorder of benign convulsions with mild gastroenteritis (CwG), while mutations in KCNQ2 and KCNQ3 have been recognized in benign familial neonatal e...
We report a case of tuberous sclerosis in 19 years old teenage patient with generalized tonic-clonic seizure. MRI brain showed linear CSF filled structure surrounding gliosis extending from the frontal horn right lateral ventricle to pial surface lobe-postoperative change. Multiple small T2/ FLAIR hyper-intensities without diffusion restriction bilateral temporal parietal and left occipital lob...
Background: Sleep Seizures (SSs) generally occur in refractory focal epilepsy, but their detailed characteristics and circadian patterns are still controversial. The effect of SSs on epilepsy surgery outcome has been addressed in few studies without definitive prognostic value. Objectives: This study investigated the characteristics of SSs and their prognosis in refractory focal epilepsy. M...
Tuberous sclerosis complex (TSC) is a rare disorder of tissue growth and differentiation, characterized by benign hamartomas in the brain and other organs. Up to 90% of TSC patients develop epilepsy and 50% become medically intractable requiring resective surgery. The surgical outcome of TSC patients depends on the accurate identification of the epileptogenic zone consisting of tubers and the s...
Human micturition is physiologically controlled via a complex and finely tuned network of cortical and subcortical regions, hitherto not fully understood. We report the case of a 42-year-old man with juvenile myoclonic epilepsy (JME) and post-traumatic epilepsy. Ictal enuresis was the only manifestation of the de novo post-traumatic simple autonomic seizures. Source analysis of the ictal epilep...
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