OBJECTIVE Extracellular ATP has been reported as an important signaling molecule mediating quite divergent specific biological effects. Recent clinical trials suggest a potential role of ATP in cancer treatment. The aim of our study was to analyze the mechanisms of UTP in comparison to ATP-mediated cell death in an established cell line model (A-431). METHODS Cell culture and proliferation as...

Hepatitis C Virus NS5A Protein Interacts with Phosphatidylinositol 4-kinase Type III and Regulates Viral Propagation Yun-Sook Lim and Soon B. Hwang* From the National Research Laboratory of Hepatitis C Virus, Ilsong Institute of Life Science, Hallym University, Anyang, 431-060, Korea Running head: HCV NS5A modulates PI4KIII * Address correspondence to: Soon B. Hwang, Ph.D. Ilsong Institute o...

Synthesis of (S)-Ketorolac Phil S. Baran*, Jeremy M. Richter and David W. Lin SUPPORTING INFORMATION General Procedures. All reactions were carried out under a nitrogen atmosphere with dry solvents under anhydrous conditions, unless otherwise noted. Dry tetrahydrofuran (THF), triethylamine, benzene, and dimethoxyethane were obtained by passing commercially available pre-dried, oxygen-free formu...

In Pseudomonas aeruginosa, conversion to the mucoid phenotype marks the onset of an irreversible state of the infection in Cystic Fibrosis (CF) patients. The main pathway for mucoid conversion is mutagenesis of the mucA gene, frequently due to -1 bp deletions in a simple sequence repeat (SSR) of 5 Gs (G(5)-SSR(426)). We have recently observed that this mucA mutation is particularly accentuated ...

With the current emergence of green chemistry to keep the environment safe, attention is being shifted towards using plant extracts as corrosion inhibitors. The inhibitive performances of Talinum triangulare leaf extract and Musa sapientum peel extract on the ZA-27 in 1.0 M and 1.5 M hydrochloric acid solutions were studied for 18 days using mass loss measurement. The corrosion inhibition effic...