نتایج جستجو برای: bax inhibitor 1 like protein
تعداد نتایج: 4108528 فیلتر نتایج به سال:
It was previously reported that the histone deacetylase inhibitor (HDACI) trichostatin A (TSA) induced B cell lymphoma 2 (Bcl-2)-associated X protein (Bax)-dependent apoptosis in colorectal cancer (CRC) cells. In addition, Ku70 has been identified as a regulator of apoptosis, the mechanism of which proceeds via interacting with Bax. The aim of the present study was to investigate the role of Ku...
Bax inhibitor-1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats
Latent membrane protein 1 (LMP-1) of Epstein-Barr virus (EBV) promotes tumorigenesis by inhibiting apoptosis. We show that an important antiapoptotic activity of LMP-1 is the inhibition of Bcl2-associated protein X (Bax), a potent proapoptotic protein. BAX expression was regulated by LMP-1 activation of nuclear factor kappaB (NF-kappaB) via the C-terminal activation region 1 (CTAR-1) and CTAR-2...
Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila.
Bcl-2 family proteins regulate cell death through the mitochondrial apoptotic pathway. Here, we show that the Drosophila Bax-like Bcl-2 family protein Drob-1 maintains mitochondrial function to protect cells from neurodegeneration. A pan-neuronal knockdown of Drob-1 results in lower locomotor activity and a shorter lifespan in adult flies. Either the RNAi-mediated downregulation of Drob-1 or ov...
برنج یکی از غلات دانه ریز مهم در جهان است که بیش از 50% از جمعیت جهان را تغذیه می کند. عامل بیماری بلاست برنج، بیمارگر magnaporthe grisea است که یکی از مهم ترین بیماری های قارچی برنج در اغلب نواحی جهان به شمار می رود. به منظور بررسی اثر تنش قارچ بلاست بر الگوی بیان پروتئوم در کشت سوسپانسیون سلولی برنج، آزمایشی در قالب طرح کاملا تصادفی با دو رقم نعمت و طارم در دو سطح شاهد و تنش بیماری بلاست در س...
Bax is a pro-apoptotic cytosolic protein. In this work native (unphosphorylated) and JNK3 phosphorylated Bax proteins are studied on artificial bilayer membranes for pore formation. Phosphorylated Bax formed pore on the bilayer lipid membrane whereas native one does not. In cells undergoing apoptosis the pore formed by the phosphorylated Bax could be important in cytochrome c release from the m...
Constitutive overexpression of insulin-like growth factor-1 (IGF-1) in myocytes protects them from apoptosis and interferes with myocyte hypertrophy in the normal and pathological heart. Conversely, angiotensin II (Ang II) triggers cell death and promotes myocyte hypertrophy. Moreover, activation of p53 upregulates the cellular renin-angiotensin system (RAS). Therefore, IGF-1 overexpression in ...
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