Charge-transfer excitations highly depend on the electronic coupling between the donor and acceptor groups. Nitrophenolates are simple examples of charge-transfer systems where the degree of coupling differs between ortho, meta and para isomers. Here we report the absorption spectra of the isolated anions in vacuo to avoid the complications of solvent effects. Gas-phase action spectroscopy was ...

Under prolonged diabetic conditions, HbA1c is produced from normal hemoglobin (HbA0) through a non-enzymatic glycosylation or glycation, a process which enhances the hemoglobin susceptibility to be auto-oxidized to methemoglobin (metHb). Here we are reporting that the non-enzymatic reaction between fructose and metHb (metHb fructation) induces significant changes in the gl...

Thienothiophene (TT) is one of the most impressive organic cores, and has gained significant attention in polymeric materials recent years. Possessing cyano (CN), carboxylic acid (COOH) dimethylamine (N(CH3)2) substituted thieno[3,4-b]thiophene (TT), π-extended conjugated three novel polymers (P1-P3) with 3-hexylthiophene were successfully synthesized by Suzuki coupling. All found to be well so...

A structural analysis of the recently developed orange fluorescent proteins with novel phenotypes, LSSmOrange (λex/λem at 437/572 nm), PSmOrange (λex/λem at 548/565 nm and for photoconverted form at 636/662 nm) and PSmOrange2 (λex/λem at 546/561 nm and for photoconverted form at 619/651 nm), is presented. The obtained crystallographic structures provide an understanding of how the ensemble of a...

A series of previously unknown bridgehead-functionalized bicyclo[2.2.2]octasilanes, Me3Si-Si8Me12-X, X-Si8Me12-X, and X-Si8Me12-Y [X, Y = -SiMe n Ph3-n (n = 1, 2) (2, 3, 10), -SiMe2Fc (Fc = ferrocenyl) (4, 11, 13, 14), -COR (R = Me, tBu) (6, 7, 12), COOMe (8), COOH (9)], have been prepared by the reaction of the silanides Me3Si-Si8Me12-K+ or K+-Si8Me12-K+ with proper electrophiles and fully cha...

The 8000 X g pellet of rabbit placenta transformed arachidonic acid into a number of lipoxygenase and cyclooxygenase products of known structure. A metabolite was also produced which was inhibited by indomethacin and required calcium for its formation. This compound had a UV absorption maximum at 227 nm under acidic or neutral conditions and gave a bathochromic shift to 281 nm under alkaline co...

Ellipticine (NSC 71795), a plant alkaloid with antitumor activity, is a weakly basic polycyclic molecule with dimensions similar to those of proflavin. Like proflavin, ellipticine exhibits hypocromic and bathochromic changes in absorption spectrum in the presence of DNA. It binds preferentially to helical DNA by intercalation, but the strength of binding is substantially greater than that of pr...

Photodynamic therapy is an advanced method of treating cancer and various benign diseases, including infections. It uses light-activated molecules [photosensitizers (PSs)] to generate reactive oxygen species (ROS) when irradiated with light of a specific wavelength. This study examined the photophysical and photosensitizing activity of the PS chlorin e6 incorporated in a delivery system based o...

In addition to the isoflavonoid phytoalexins re­ ported earlier [1], the mung bean, Phaseolus aureus, produces coumestrol ( 1 ) and two novel coumestans, aureol (2) and phaseol (3). Coumestrol has been isolated from this plant previously [2 ] and the present communication describes the isolation and structural characterization of the latter two com­ pounds. The characterizations of aureol and p...