Electron microscopic cytochemical studies of the basement membranes of myocardial cells and capillaries were performed in 13 patients with tetralogy of Fallot who were divided into 2 groups. Group 1 included 7 patients in the early stage of the disease, ranging in age from 7 months to 5 years. Group 2 consisted of 6 patients in the far advanced stage of the disease, ranging in age from 30 to 46...

Immunohistochemistry was used to identify basement membrane components and examine their production by associated cells. Four substances were identified in a series of basement membranes in rats aged 20 days to 34 months, namely, type IV collagen, laminin, heparan sulfate proteoglycan, and fibronectin. They were then all localized to the basal lamina part of basement membranes and, presumably, ...

[1] Single-hole hydrogeologic experiments were conducted with a drillstring packer in Integrated Ocean Drilling Program Hole 1301B, which penetrates 318 m into 3.5-Ma upper oceanic basement on the eastern flank of the Juan de Fuca Ridge. Seven constant-rate injection tests were conducted in open hole, with the packer inflated at three depths in the deepest 166 m of the basement section. The pri...

The matricellular glycoprotein SPARC (secreted protein, acidic and rich in cysteine), also termed osteonectin, has been found to regulate the invasive behaviour of several tumour types by interacting with basement membrane constituents. Brain invasive meningiomas are supposed to disrupt the pial-glial basement membrane. In the present study we aimed at determining the relationship of basement m...

The capillaries of overacting inferior oblique muscles from children with strabismus and of dog inferior oblique muscles were ultrastructurally described. Biopsy material was used in all instances. The mean diameter of the capillary lumen was 2.03 microns for the human inferior oblique and 2.76 microns for the dog inferior oblique. Quantitative estimates of capillary basement membrane width wer...

Skin in the tadpole of anuran larvae prior to metamorphosis is composed of two layers of epidermal cells (Leeson and Threadgold, 1961; Chapman and Dawson, 1961; Edds and Sweeny, 1960, 1962), a laminated basement lamella, and a layer of dermal mesenchyme cells apposed to the underside of the basement lamella. An adepidermal space and membrane (Salpeter and Singer, 1959, 1960) separate epidermis ...

I t is generally agreed that the hepatic sinusoidal lining is discontinuous and that no basement membrane as such exists in the livers of rats (7-9, 14-16, 19, 20, 22), mice (5, 10, 11, 21), dogs (16), rabbits (1, 18), pig embryos (1), frogs (8), developed chick embryos (12), and humans (4, 6, 16). However, several investigators have called attention to patches of "basement membranel ike" mater...

Samples of human plantar and palmar skin were excised and incubated in 20 mM EDTA after which the epidermis was gently separated from the dermis with the plane of separation occurring in the lamina lucida. Scanning electron microscopic examination of the dermal component revealed the classically described series of regularly spaced grooves and papillae that characterize the epidermal-dermal jun...

Reconstituted basement membranes and extracellular matrices have been demonstrated to affect, positively and dramatically, the production of milk proteins in cultured mammary epithelial cells. Here we show that both the expression and the deposition of extracellular matrix components themselves are regulated by substratum. The steady-state levels of the laminin, type IV collagen, and fibronecti...