In children with acquired oesophageal strictures * even without a definite history of ingestion, there could be a foreign body in the oesophagus * diagnostic work-up in cases of suspected 'occult foreign body' still presents difficulties, particularly if the foreign body is radiolucent * the chronic presence of a foreign body in the oesophagus may lead to severe and unsuspected complications a ...

BACKGROUND Columnar lined (Barrett's) oesophagus is often considered a sequel to chronic severe reflux disease. Aberrant lower oesophageal sphincter (LOS) motility associated with Barrett's oesophagus includes reduced basal LOS pressures. The aim of this study was to characterise neuromuscular function of the LOS in normal (squamous cell carcinoma (SCC) with uninvolved LOS) and reflux affected ...

N-nitrosodiethylamine (NDEA) is able to induce tumours in the rat oesophagus. It has been suggested that this could be due to tissue specific expression of NDEA activating cytochrome P450 enzymes. We investigated this by characterizing the oesophageal monooxygenase complex of male Wistar rats and comparing it with that of the liver. Total amount of cytochrome P450, NADPH P450 reductase, cytochr...

BACKGROUND AND AIMS Approximately 10% of adults experience gastro-oesophageal reflux symptoms with a variable oesophageal response. A total of 60% have no endoscopic abnormality, 30% have oesophagitis, and 10% have Barrett's oesophagus. We investigated whether the inflammatory cell infiltrate and cytokine profiles of these clinical phenotypes merely vary in severity or are fundamentally differe...

Congenital anomalies of the oesophagus were once thought to be relatively rare. Plass in 1919 reported one case and in an exhaustive review of the literature found 136 fully verified cases; he stated that there was some variation in the minor details of the anomaly, but the general picture was uniform -a blind upper pouch ending at a level between the lower border of the larynx and the tracheal...