We first study the conf relation proposed by E. Brinksma and G. Scollo to formalize testing conformance. It is well-known from their work that, in order to test whether an implementation I is a valid implementation of a specification S (i.e. I conf S), it suffices to build, from S, a canonical tester T (S) such that, when T (S) is synchronized with an implementation I, it always reaches a corre...

BACKGROUND Occipital nerve stimulation (ONS) has raised new hope for drug-resistant chronic cluster headache (drCCH), a devastating condition. However its mode of action remains elusive. Since the long delay to meaningful effect suggests that ONS induces slow neuromodulation, we have searched for changes in central pain-control areas using metabolic neuroimaging. METHODS Ten drCCH patients un...

OBJECTIVES To assess, by magnetic resonance imaging, the volumes and magnetization transfer ratio (MTR) values of optic nerves (ONs) from patients with multiple sclerosis (MS) who had incomplete or no visual recovery after optic neuritis; and to compare these quantities with those derived from ONs from patients with MS who showed a marked clinical recovery after optic neuritis, ONs from healthy...

ONS-3010 is being developed by Oncobiologics Inc. (Cranbury, NJ, USA) as a biosimilar of Humira®. This randomized, double blind, single-center phase I study (EudraCT registration # 2013-003551-38) was performed to demonstrate pharmacokinetic (PK) biosimilarity between two reference products (Humira® EU and US) and ONS-3010 in healthy volunteers, and to compare the safety and immunogenicity prof...

The fluorination of [MeAlN(2,6-i-Pr2C6H3)]3 1 using 1 and 2 eq., respectively, trimethyltin fluoride leads to the monoand difluoro compounds, [FAl(MeAl)2(N(2,6-i-Pr2C6H3))3] 2THF 2 and [(FAl)2MeAl(N(2,6-i-Pr2C6H3))3] 3THF 3, where each methyl group can be selectively exchanged for terminal fluorine atoms (Al–F). The reaction of 1 and 3 eq. of trimethyltin fluoride leads to the trifluoro compoun...

Este trabajo pretende indagar en la existencia de relación entre Inteligencia Emocional y el Rendimiento Académico que permita mejorar asesoramiento especializado orientación educativa psicopedagógica a los profesionales centros educativos. Concretamente se estudia las variables calificaciones obtenidas por estudiantes materias instrumentales básicas. Para ello, ha contado con una muestra 976 p...

BACKGROUND This study sought to map the Insomnia Severity Index (ISI) and symptom variables onto the EQ-5D. METHODS A cross-sectional survey was conducted among adult US residents with self-reported sleep problems. Respondents provided demographic, comorbidity, and sleep-related information and had completed the ISI and the EQ-5D profile. Respondents were classified into ISI categories indica...