We developed and compared two mathematical models of variable phenotypic switching rates between normal and persister cells that depend on substrate concentration and antibiotic presence. They could be used to simulate the formation of persisters in environments with concentration gradients such as biofilms. Our models are extensions of a previous model of the dynamics of normal and persistent ...

Quantitative structure-toxicity relationship (QSTR) plays an important role in toxicity prediction. With the modified method, the quantum chemistry parameters of 57 benzoic acid compounds were calculated with modified molecular connectivity index (MCI) using Visual Basic Program Software, and the QSTR of benzoic acid compounds in mice via oral LD(50) (acute toxicity) was studied. A model was bu...

1. Sackley CM, Hoppitt TJ, Wright CC et al. A cluser randomised controlled trial of physiotherapy and occupational therapy intervention to enhance mobilty and activity in care home residents. BMJ 2009; 339: 670–3. 2. Hellstrom K, Lindmark B, Fugl-Meyer A. The Falls-Efficacy Scale, Swedish version: does it reflect clinically meaningful changes after stroke? Disabil Rehabil 2002; 24: 471–81. 3. R...

Here j is a positive rational number and p = 0 or 1. Also using resolution of singularities, it can be shown that (j, p) is independent of U for small enough U . We refer to j as the growth index of S and to p as the multiplicity of this growth index. If S(x, y) is merely smooth, then it follows from [G1] that (1.2) still holds unless there is a smooth coordinate change fixing the origin after ...

BACKGROUND Recent reports critical of the performance of heart rate-adjusted indexes of ST depression during exercise electrocardiography have used J-point rather than ST segment measurements. However, no standard exists for the optimal time after the J-point at which to measure ST segment deviation. METHODS AND RESULTS To assess the effect of ST segment measurement position on performance of...