Respiratory tract infections are a major global health concern, accounting for high morbidity and mortality, especially in young children and elderly individuals. Traditionally, highly common bacterial respiratory tract infections, including otitis media and pneumonia, were thought to be caused by a limited number of pathogens including Streptococcus pneumoniae and Haemophilus influenzae. Howev...

Underproduction of hydrochloric acid into the stomach is frequently encountered in subjects from developing countries. We explore the hypothesis that hypochlorhydria compromises the gastric barrier and favours bacterial overgrowth in the proximal parts of the small intestine where nutrient absorption takes place. Food calories are thus deviated into bacterial metabolism. In addition to an adequ...

Bacterial overgrowth and high intraluminal concentrations of deconjugated bile acids are thought to be responsible for mucosal hyperplasia in self-filling blind loops of rat jejunum. To investigate this hypothesis further we have assessed the three dimensional architecture of these loops created in germ free animals without or with di- or mono-association of different bacterial species. It was ...

BACKGROUND Intestinal ischemia/reperfusion injury (I/R) is a significant cause of morbidity and mortality in surgical patients. Ceramide is a mediator of apoptosis and has been implicated as increasing bacterial infection susceptibility. The metabolite of ceramide, sphingosine, was recently shown to play an important role in the cell-autonomous, innate immune response of the upper respiratory t...

Variations in the basic parameters of electrical activity small intestine rats were studied using an experimental model hypochlorhydria caused by intragastric administration rabeprazole for 16 days. Hypochlorhydria was found to lead increased duration irregular electric and a reduction period quiescence, which indicates increase uncoordinated contractions intestine. A decrease number migrating ...

AMA Wasielewska Z, Krogulska A, Szaflarska-Popławska A. Proton pump inhibitors – their possible influence on the development of small intestine bacterial overgrowth in children. Pediatria Polska - Polish Journal Paediatrics. 2023. doi:10.5114/polp.2023.128720. APA Wasielewska, Z., Krogulska, A., & Szaflarska-Popławska, (2023). https://doi.org/10.5114/polp.2023.128720 Chicago Zuzanna, Aneta and ...